degree of urgency, maternal status and desire of patient. Use of regional anesthesia has dramatically increased and use of general anesthesia for cesarean section has been steadily decreasing. [1] Risk of general anesthesia includes failed endotracheal intubation, failed ventilation, aspiration pneumonitis, postoperative nausea and vomiting, neonatal depression, and maternal awareness. [2] Although spinal block provide excellent anesthesia for cesarean section it is frequently accompanied by hypotension generally proportional to the degree (level) of sympathectomy (height of block). [3] Many methods to decrease the risk of hypotension have been studied, which include ensuring proper maternal position with uterus displaced off vena cava, infusion of fluids to increase effective blood volume, administration of Original Article A B S T R A C TBackground: Spinal block provides excellent anesthesia for cesarean section, but it is frequently accompanied by hypotension, which if untreated can pose serious risks to mother and baby. Over the years, many interventions have been tried to prevent hypotension, but no single technique has proven to be effective and reliable. This study was carried out with the aim to find if wrapping the legs with elastic crepe bandage in addition to traditional methods was effective in preventing post spinal hypotension. Materials and Methods: A total of 60 full-term parturients with an uncomplicated pregnancy belonging to American Society of Anesthesiologists I or II were allocated randomly (30 in each group) to have their legs wrapped with elastic crepe bandage or no wrapping was done. All patients received intravenous (IV) crystalloid (20 ml/kg) 15 min prior to spinal injection and were placed in left lateral position. Electrocardiography and oxygen saturation was monitored continuously and heart rate, blood pressure was measured every 2 min until delivery of baby and every 5 min thereafter until end of cesarean section. Significant hypotension was treated with IV phenylephrine 50 µg bolus doses. Results: The frequency of hypotension was significantly less (P = 0.009) in Group B (legs wrapped group) 3 (10%) patients when compared with Group A (nonleg wrapped) 13 (43.33%). In Group A 10 (33.33%) patients and in Group B 3 (10%) patients required rescue dose with phenylephrine which was statistically significant (P = 0.0003). Difference in the "mean change of arterial pressure" between Group A and B was highly significant (P < 0.001) recorded at 4, 6, and 8 min. Conclusion: Incidence of hypotension can be reduced by wrapping the legs with elastic crepe bandage with a subsequent reduction in the use of potent vasopressor. Since leg wrapping with crepe bandage is cheap, easy, readily available, noninvasive, and nonpharmacological method, it can be recommended for preventing post spinal hypotension in a developing country like ours.
Introduction:Human papilloma virus (HPV) which is causative factor for cervical cancer may interact with p16 leading to malignant transformation of cervical epithelial cells. The present study was conducted to assess the immunoexpression of p16 INK4a in premalignant and malignant lesions of cervix and to correlate it with HPV 16 expression. It was also intended to study the various risk factors which may be associated with cervical cancer in this north Himalayan region of India.Material and Methods:The study included 50 cases of premalignant and malignant cervical lesions and 50 controls diagnosed on histopathology over a period of one year. All the relevant clinical details were noted and both cases and controls were subjected to HPV 16 and p16 INK4a immunohistochemical staining.Results:67% of subjects (including cases and controls) and 94% of the cases were positive for HPV 16 expression. p16 INK4a expression was negative in all the controls, positive in 96% of invasive cancer, 66.6% in HSIL and 37.5% in LSIL.Conclusion:Cervical cancer is associated with low socio economic status, illiteracy, smoking, early age of marriage and conception in north Himalayan region of India. HPV 16 infection is positive in both cases and controls indicating high prevalence of HPV 16 in this region. Neoplastic transformation by HPV is identified by over expression of p16 INK4a in premalignant and malignant cases. The immunopositivity of p16 INK4a increases with the severity of cervical lesions and thus may play an important role in stratification of premalignant and malignant lesions.
Abstract:Introduction: Maternal morbidity and mortality in India continues to remain high despite concerted efforts during the past decades. Objective of this study was to determine the prevalence and indicator of Potentially Life Threatening Conditions (PLTC) and 'near miss' obstetric cases at different tiers of health care. Material and Methods: A cross-sectional epidemiological study was carried out over a period of 12 months as per the WHO criteria for 'near miss'. Probability sampling was done to systematically and randomly select health facilities i.e. two primary health centers (PHC), one community health centre (CHC) and a tertiary hospital all from Doiwala block of Dehradun, Uttarakhand, India. The study included all the women attending health-care facilities, who were pregnant, in labour, or who had delivered or aborted up to 42 days ago arriving at the facility. A convenient sampling was done (a hundred percent enumeration of eligible study subjects) for the audit. Result: A total of 937 pregnant women who accessed health care had 688 live births and 231 women had one or more of the Potentially Life Threatening Conditions (PLTC). Among them, 61 women had Severe Maternal Outcome (SMO) -51 with maternal 'near-miss' and 10 maternal deaths. The Severe Maternal Outcome Ratio (per 1000 live births) was 88.66. The Maternal 'near miss' Mortality Ratio (MNM-MR) and Mortality Index (MI) were 5.1 and 16.39% respectively. Conclusion: The WHO 'near miss' approach has been found to be an effective measure to assess quality of care in maternal health across countries including India.
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