Plasma-sprayed hydroxyapatite coated (HAC) 50 and 200 microns thick on Ti-6Al-4V cylinders was transcortically implanted in the femora of canines to evaluate in detail the effect of coating thickness on the pushout shear strength and failure mode examined under scanning electron microscope after the periods of 4, 6, 8, and 12 weeks. The HAC coating exhibited higher shear strength at 50 microns than at 200 microns. Its failure mode was conclusively at or near the HAC-bone interface, and the slight attack of body fluid had not degraded the implant to the extent that failure occurred at the HAC-Ti alloy interface after 12 weeks of observation. For 200 microns-HAC, failure was found at the HAC-bond interface, inside the HAC lamellar splat layer and at the HAC-Ti alloy substrate interface, depending on the period of implantation. It was also deduced that the variation of failure mode of 200 microns-HAC with time could not be accounted for by the attack of body fluid alone; the degradation must be a synergetic adverse result of residual stress in the HAC and the attack of body fluid.
A quantitative evaluation, at the scanning electron microscopic (SEM) level, was made of the osteoconduction and osseointegration of Ti-6AI-4V implants with and without plasmasprayed hydroxyapatite coatings (HACs). By employing the Chinese Coin implant model in the lateral femora cortices of canines, different biological properties between HA-coated and uncoated Ti-6AI-4V implants could be compared in one specimen. After 4, 6 and 1 2 weeks, the implants with surrounding bone were removed and assessed histologically in undecalcified sections under SEM. The osteoconductivity and the ability of osseointegration of implants were histomorphometrically analysed from back-scattered electron images (BEIs) and represented in terms of the new bone healing index (NBHI) and apposition index (AI), respectively. Throughout all implant periods, the HA-coated Ti-6AI-4V implants revealed higher NBHI than the uncoated ones, it appearing that the HA-coated Ti-6AI-4V.implant was more osteoconductive than the Ti-6AI-4V was. For HA-coated implant, the evidence of direct bone-to-HAC contact was observed. However, at the bone/Ti-6AI-4V interface, there intervened a fibrous membrane without calcium content, indicating that the Ti-6AI-4V implant was not osseointegrated in the SEM field of view. The maximum value of AI was reached 6 weeks after implantation for HA-coated implant, implying that the HAC had a stimulating influence on bone apposition within 6 weeks of healing. The signs of partial dissolution of HACs within the remodelling canals were evident at the HAC-bone interface 1 2 weeks after implantation, accounting for the slight decrease in NBHI and the obvious decrease in AI for HAC implant.
An intramedullary implant model in the canine femora was developed to evaluate the mechanical and histological responses between cancellous bone and plasma-sprayed hydroxyapatite coatings (HACs) on ti-6A1-4V implants, with 12- and 24-week follow-ups. HACs of different thicknesses were investigated. Results of the mechanical testings revealed that after 24 weeks of implantation, the mean shear strength (2.49 +/- 0.12 MPa) of the 50 microns HACs was significantly higher (p < 0.05) than that of the 200 microns HACs (1.44 +/- 0.19 MPa). However, using backscattered electron images (BEIs) throughout all the implant periods, no substantial histological variations in the extent of new bone apposition between the two HACs were observed. Occasionally, solution-mediated disintegration of the 50 microns HAC was found 24 weeks postimplantation. Histomorphometric studies from the BEIs demonstrated that for both HACs the percentage of the direct HAC-cancellous bone contact was approximately 50% at 12 weeks and 75% at 24 weeks. After the mechanical tests, the 200 microns HACs had fracture sites either inside the coating layers or at the HAC-titanium interfaces, which might explain why the mechanical performance of the 200 microns HACs was inferior to that of the 50 microns HACs even though both HACs had the same histological behaviors.
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