The shear strength and the failure mode of plasma‐sprayed hydroxyapatite coating to bone: The effect of coating thickness

Wang, B. C.; Lee, Tse‐Min; Chang, Edward F.; Yang, Chih Hai

doi:10.1002/jbm.820271012

Cited by 146 publications

(94 citation statements)

References 21 publications

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“…However, the interface between the coating and the implant may become the weak point of the system [31]. This problem was solved by decreasing the HA coating thickness [41].…”

Section: Introductionmentioning

confidence: 99%

Calcium phosphate drug delivery system: influence of local zoledronate release on bone implant osteointegration

Peter

Pioletti

Laı̈b

et al. 2005

Bone

249

167

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Despite total hip replacement (THR) gives generally satisfactory results, the quality of outcome in young patients is markedly decreased compared to the average THR outcome. For this population, pharmacological treatment with bisphosphonate would be beneficial to decrease the peri-implant osteolysis. However, as this population does not necessarily suffer from osteoporosis, a nonsystemic treatment would be preferable. Zoledronate was then grafted to hydroxyapatite (HA) coating of titanium implants. The implants were inserted in rat condyles with various zoledronate concentrations. A positive concentration-dependent effect was observed on the peri-implant bone density and on different histomorphometric parameters. Importantly for the outcome of the implants, the mechanical fixation was increased by the local presence of zoledronate.The obtained results open the way of an easy transformation of currently existing HA-coated implants by grafting bisphosphonate onto the coating in order to increase their service life in the patients. D 2004 Elsevier Inc. All rights reserved.

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“…However, the interface between the coating and the implant may become the weak point of the system [31]. This problem was solved by decreasing the HA coating thickness [41].…”

Section: Introductionmentioning

confidence: 99%

Calcium phosphate drug delivery system: influence of local zoledronate release on bone implant osteointegration

Peter

Pioletti

Laı̈b

et al. 2005

Bone

249

167

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“…A thicker coating usually exhibits poorer mechanical properties. The suggested optimum thickness is about 50 mm in order to avoid fatigue failure while still providing reasonable coating bioresorption and consistent bone growth [249][250][251][252]. A 50 mm coating exhibits significantly higher shear strength than a 200 mm coating.…”

mentioning

confidence: 99%

Surface modification of titanium, titanium alloys, and related materials for biomedical applications

Liu

Chu

Ding

2004

Materials Science and Engineering: R: Reports

2,959

1,477

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Titanium and titanium alloys are widely used in biomedical devices and components, especially as hard tissue replacements as well as in cardiac and cardiovascular applications, because of their desirable properties, such as relatively low modulus, good fatigue strength, formability, machinability, corrosion resistance, and biocompatibility. However, titanium and its alloys cannot meet all of the clinical requirements. Therefore, in order to improve the biological, chemical, and mechanical properties, surface modification is often performed. This article reviews the various surface modification technologies pertaining to titanium and titanium alloys including mechanical treatment, thermal spraying, sol-gel, chemical and electrochemical treatment, and ion implantation from the perspective of biomedical engineering. Recent work has shown that the wear resistance, corrosion resistance, and biological properties of titanium and titanium alloys can be improved selectively using the appropriate surface treatment techniques while the desirable bulk attributes of the materials are retained. The proper surface treatment expands the use of titanium and titanium alloys in the biomedical fields. Some of the recent applications are also discussed in this paper. #

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“…However, disadvantages of these implants are always concerning, including detachment and bioresorption of the coating film and rapid progress of inflammatory symptoms 19) . There have been efforts to address these concerns by improving the crystallization ratio of the coated hydroxyapatite and by strengthening the bond between titanium and hydroxyapatite 20,21) . Studies have also been conducted using a thin coating layer of 1-5 m with the premise that there may be hydroxyapatite bioresorption and disappearance during or after achievement of osseointegration [22][23][24] .…”

Section: Introductionmentioning

confidence: 99%

The Effect of Implant Surfaces sputter-coated with Hydroxyapatite Target

Sakai

Okamura

Watazu

et al. 2013

J. Hard Tissue Biology.

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The aim of this study was to develop experimental titanium implants sputter-coated from a hydroxyapatite target and to evaluate peri-implant tissue responses in an animal experiment. The experimental implants were prepared from plastic rods, each of which was 1.6 mm in diameter and 7 mm in length. A thin titanium film was deposited onto the rods by DC magnetron sputtering. The surface of each rod was subsequently sputter-coated from a hydroxyapatite target by RF magnetron sputtering. The experimental implants were placed in the tibiae of 8-week-old male SD rats. Titanium-coated implants were placed as controls using the same method. Tissue samples were obtained 3, 5, 7, 10, 14, and 28 days after implant placement. Histological evaluation was performed using a light microscope, and the bone-implant contact ratios (BICs) were measured. Microstructural observations of implant-bone interfaces were made using a transmission electron microscope (TEM). Peri-implant osteoblastic activity was evaluated using samples obtained 5, 7, and 10 days after implant placement. Immunohistochemical evaluation of type I collagen, osteopontin, and osteocalcin was performed. Uniform smoothness of experimental implant surfaces was confirmed by scanning electron microscope(SEM) images. In the calcium phosphate layer, the compositional ratio of the experimental implant surface was Ca:P:O=1.0:0.79:2.8 based on the results of X-ray photoelectron spectroscopy(XPS). In the trabecular bone region, the BIC ratio was significantly higher in the experimental group than in the control group at 5, 7, 10, and 28 days after implant placement. Type I collagen, osteopontin, and osteocalcin immunostaining revealed that the experimental group tended to show positive results earlier than the control group. The results of this study suggest that surface treatment using a hydroxyapatite target and RF magnetron sputtering can enhance new bone formation during implant osseointegration.

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The shear strength and the failure mode of plasma‐sprayed hydroxyapatite coating to bone: The effect of coating thickness

Cited by 146 publications

References 21 publications

Calcium phosphate drug delivery system: influence of local zoledronate release on bone implant osteointegration

Calcium phosphate drug delivery system: influence of local zoledronate release on bone implant osteointegration

Surface modification of titanium, titanium alloys, and related materials for biomedical applications

The Effect of Implant Surfaces sputter-coated with Hydroxyapatite Target

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