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This systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to summarize the effect of selenium administration on glucose metabolism and lipid profiles among patients with diseases related to metabolic syndrome (MetS). We searched the following databases up to May 2017: MEDLINE, EMBASE, Web of Science, and Cochrane Central Register of Controlled Trials. The relevant data were extracted and assessed for quality of the studies according to the Cochrane risk of bias tool. Data were pooled using the inverse variance method and expressed as standardized mean difference (MDs) with 95% confidence intervals (95% CI). Five studies were included in the meta-analyses. The results showed that selenium supplementation significantly reduced insulin levels (SMD -0.42; 95% CI, -0.83 to -0.01) and increased quantitative insulin sensitivity check index (QUICKI) (SMD 0.83; 95% CI, 0.58 to 1.09). Selenium supplementation had no beneficial effects on other glucose homeostasis parameters, such as fasting plasma glucose (FPG) (SMD -0.29; 95% CI, -0.73 to 0.15), homeostasis model assessment of insulin resistance (HOMA-IR) (SMD -0.80; 95% CI, -1.58 to -0.03), and lipid profiles, such as triglycerides (SMD -0.42; 95% CI, -0.83 to -0.01), VLDL- (SMD -0.42; 95% CI, -0.83 to -0.01), total- (SMD -0.42; 95% CI, -0.83 to -0.01), LDL- (SMD 0.02; 95% CI, -0.20 to 0.24), and HDL-cholesterol (SMD 0.16; 95% CI, -0.06 to -0.38). Overall, this meta-analysis showed that selenium administration may lead to an improvement in insulin and QUICKI, but did not affect FPG, HOMA-IR, and lipid profiles.

Background & Objective: The thymus gland significantly affects fetal immune system maturation. Additionally, there is a linear association between thymus gland size and its performance. Given the high prevalence of vitamin D deficiency in Iran and scarce studies with conflicting results, subjecting maternal vitamin D concentration effect on fetal thymus, we decided to investigate maternal vitamin D concentration and its relation to fetal thymus size in mid-gestation. This study also aimed to generate a race-specific reference range. Materials & Methods:We performed a cross-sectional study of ultrasound measurements of the fetal thymus at 18-22 weeks of gestational age in 94 pregnant women and its correlation with maternal serum vitamin D levels from May to July 2021 at the tertiary center of Imam Khomeini Hospital in Tehran, Iran. Results:The mean values of thymus perimeter, thymus-thoracic ratio, thymus transverse diameter, and thymus area in all participants were 4.18±0.56 cm, 0.37±0.04, 1.56±0.21 cm, and 1.11±0.76 cm 2 , respectively. There was a trend toward decreased thymus perimeter and transverse thymus diameter with decreasing level of maternal vitamin D. There was also a significant correlation between thymus perimeter and transverse thymus diameter with fetal biometric indices and gestational age. Furthermore, a significant correlation was observed between the thymus perimeter and transverse thymus diameter. Conclusion:We generated a race-specific nomogram for fetal thymus size in Iranian pregnant women. Moreover, the observed trend toward decreased fetal thymus size with decreasing maternal vitamin D levels requires further prospective investigations. A high prevalence of vitamin D deficiency and low compliance with daily vitamin D intake during pregnancy was also shown, which requires a solution.

Background: Early-onset neonatal sepsis (EOS) is a systemic infection that occurs within the first week of life. Objectives: This study investigated the association of serum vitamin D levels in pregnant women and their neonates with the prevalence of EOS. Methods: This case-control study was performed among 50 term/late pre-term neonates admitted to our NICU due to EOS, alongside 50 healthy neonates matched for gestational age range and sex. Maternal and neonatal serum vitamin D levels were measured. The criteria for diagnosing EOS included any/combination of: respiratory, cardiovascular, hemodynamic, neurological, gastrointestinal, body temperature, or metabolic signs. For sepsis cases, CBC, CRP, blood type, blood culture, chest X ray, and in some cases, and CSF analysis and culture were tested. Mothers’ clinical history was collected. Results: Each group included 30 (60%) male and 20 (40%) female neonates. Birth weight averages were 2772 ± 667 and 3215 ± 349 grams in the case and control groups, respectively (P < 0.001). The mean serum vitamin D levels were 49.75 ± 25.53 and 56.41 ± 18.17 nmol/L in the case and control groups, respectively. The control group mothers had a significantly higher vitamin D level (68.24 nmol/L versus 55.01 in mothers of sepsis cases, p=0.005) and showed a correlation with the vitamin D levels of their neonates (R = 0.731, P < 0.001), while the data failed to show a correlation between vitamin D level in mothers and their neonates in the sepsis group (R = 0.241, P = 0.115). C-section delivery was more prevalent among the sepsis cases (P < 0.001). Conclusions: Early-onset neonatal sepsis is associated with vitamin D deficiency in neonates and their mothers, low birth weight, and being delivered by C-section.

Background and Objective: Tokophobia is a manifestation of severe anxiety that causes fear for women. As a result, women tend to avoid having children and pregnancy due to their fear of childbirth, despite their great interest in having children and the beauty of motherhood. The present study aimed to examine the relationship between Vaginismus, Dysmenorrhea, and social support and tokophobia through the mediation of childbirth self-efficacy. Materials and Methods: The present study was a cross-sectional descriptive correlational study. The statistical population of the study consisted of all pregnant women referred to Taleghani Hospital. Out of the population, 146 pregnant women were selected as the research sample using the availability sampling technique. Research data were collected using the Tokophobia Questionnaire (2021), Multidimensional Vaginal Penetration Disorder Questionnaire (MVPDQ), Moos Menstrual Distress Questionnaire, Perceived Social Support (MSPSS), and Lowe's Childbirth Self-Efficacy Questionnaire. The collected data were then analyzed using the Smart PLS software and statistical methods of correlation and path analysis. Findings: The results showed that there was a significant relationship between, vaginismus with child birth self-efficacy (B=0.341, t=4.145, p0. 05) . Conclusion: According to the fitting indices of the model, it can be concluded that the tokophobia model has an weak fit on the basis of vaginismus, dysmenorrhea, and social support and mediating role of child birth self-efficacy

Introduction: Infant mortality is highest in preterm births. Cervical length may indicate early preterm delivery, according to studies. We assessed cervical length, gestational age, birth weight, and delivery Apgar scores. Methods: This research included 100 women bearing 100 live foetuses (mean maternal age: 29.42±6.26 years, mean gestational range 18-20 weeks). Transvaginal ultrasound measured cervical length in all women. Birth weight, gestational age, and Apgar scores were recorded. Results: 0% had cervical length less than 15 mm, 9% 15-25 mm, 75% 25-35 mm, and 16% >35 mm. ANOVA showed a significant relationship between cervical length classification and gestational age (p=0.031) and birth weight (p=0.001), but not Apgar scores (p=0.35) or gestational age at birth (p=0.29). Birth weight correlated significantly (p=0.04). Conclusions: Cervical length screening during the second trimester should be regular in selected nations or areas to decrease premature labour.