Effects of melatonin administration on mental health parameters, metabolic and genetic profiles in women with polycystic ovary syndrome: A randomized, double-blind, placebo-controlled trial

Shabani, Azade; Foroozanfard, Fatemeh; Kavossian, Elham; Aghadavod, Esmat; Ostadmohammadi, Vahidreza; Reíter, Russel J.; Eftekhar, Tahereh; Asemi, Zatollah

doi:10.1016/j.jad.2019.02.066

Cited by 62 publications

(40 citation statements)

References 40 publications

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“…2009) and in women with polycystic ovary syndrome (Shabani et al . 2019). These studies demonstrate that melatonin can be a potential therapeutic agent for the prevention of insulin resistance.…”

Section: Discussionmentioning

confidence: 99%

Effects of melatonin on insulin signaling and inflammatory pathways of rats with apical periodontitis

et al. 2021

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Aim To verify the effects of melatonin supplementation on insulin sensitivity, plasma concentrations of inflammatory cytokines, insulin signalling and inflammatory pathways in the soleus (SM) and extensor digitorum longus (EDL) muscles of rats with apical periodontitis (AP). Methodology Seventy‐two Wistar rats were distributed into 4 groups: (a) control (C), (b) control supplemented with melatonin (M), (c) AP (AP), and (d) AP supplemented with melatonin (AP + M). AP was induced by pulp exposure of the maxillary and mandibular right first and second molars to the oral environment. After AP induction, oral supplementation with 5 mg kg−1 melatonin (diluted in drinking water) for 60 days was initiated. At the end of the treatment, the following were analysed: (1) plasma concentrations of insulin and inflammatory cytokines (TNF‐α, IL‐6, IL‐1β and IL‐10) using ELISA kits; (2) glycaemia using enzymatic assay; (3) insulin resistance using homoeostasis model assessment of insulin resistance (HOMA‐IR) index; and (4) phosphorylation status of pp185 tyrosine, Akt serine, IKKα/β, and JNK in SM and EDL using Western blot. Analysis of variance of two or three factors was performed, followed by the Bonferroni test. P values < 0.05 were considered statistically significant. Results AP promoted insulin resistance, significantly increased (P < 0.05) plasma concentrations of pro‐inflammatory cytokines (TNF‐α, IL‐6, and IL‐1β), significantly decreased (P < 0.05) the concentration of anti‐inflammatory cytokine IL‐10, impaired insulin signalling in SM, and increased IKKα/β phosphorylation status in SM and EDL. Melatonin supplementation in rats with AP improved insulin sensitivity, significantly decreased (P < 0.05) TNF‐α and IL‐1β, significantly increased (P < 0.05) IL‐10 plasma concentrations, and changed the insulin signalling in soleus muscle and IKKα/β phosphorylation status in SM and EDL muscles. Conclusions Melatonin is a potent adjuvant treatment for improving apical periodontitis‐associated changes in insulin sensitivity, insulin signalling and inflammatory pathways. In addition, the negative impact of AP on general health was also demonstrated.

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Section: Discussionmentioning

confidence: 99%

Effects of melatonin on insulin signaling and inflammatory pathways of rats with apical periodontitis

et al. 2021

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“…35 In a more recent study, melatonin supplementation for 12 weeks improved sleep quality and measures of depression and was associated with lowering of insulin levels and upregulation of gene expression of peroxisome proliferator-activated receptor gamma and low-density lipoprotein receptor. 36 At this time, the significance of role of melatonin in the pathogenesis of PCOS and sleep disorders requires further investigation.…”

Section: Additional Mechanisms Linking Sleep Disturbance To Pcosmentioning

confidence: 99%

Pathogenesis and Consequences of Disordered Sleep in PCOS

Sam

Ehrmann

2019

Clin Med�Insights�Reprod�Health

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Polycystic ovary syndrome (PCOS) is a common hormonal disorder that is characterized by hyperandrogenism and menstrual irregularity. Affected women have a high prevalence of insulin resistance and related metabolic complications. The frequency of sleep disturbances appears to be increased in women with PCOS, although most studies so far have included more severely affected obese women with PCOS who are referred to tertiary care clinics and may not represent the general population of women with PCOS. This article provides an overview of sleep disturbances in PCOS with the focus on obstructive sleep apnea (OSA), the most commonly reported sleep disturbance among these women. The pathogenesis and risk factors for OSA in PCOS and its association with metabolic disorders is discussed in detail.

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“…Quite similarly, among the women (40-60 years old), those who were given melatonin for 3 months at the dose of 3 mg daily did not evoke any changes in lipid parameters [24]. On the contrary, melatonin administered at considerably higher doses (10 mg daily for 3 months) decreased total and LDL cholesterol levels, probably due to the upregulation of the expression of LDL receptor, in women with polycystic ovary syndrome [25]. Also, in diabetic patients with coronary artery disease, a higher regimen of melatonin dosing (10 mg daily for 12 weeks) improved HDL and total/HDL cholesterol ratio [26].…”

Section: Melatonin As a Beneficial Regulator Of Cholesterol Metabomentioning

confidence: 99%

The Mystery behind the Pineal Gland: Melatonin Affects the Metabolism of Cholesterol

Karolczak

Watała

2019

Oxidative Medicine and Cellular Longevity

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Melatonin may be considered a cardioprotective agent. Since atherogenesis is partly associated with the metabolism of lipoproteins, it seems plausible that melatonin affects cardiovascular risk by modulating the metabolism of cholesterol and its subfractions. Moreover, cholesterol-driven atherogenesis can be hypothetically reduced by melatonin, mainly due to the minimalization of harmful reactions triggered in the cardiovascular system by the reactive oxygen species-induced toxic derivatives of cholesterol. In this review, we attempted to summarize the available data on the hypolipemizing effects of melatonin, with some emphasis on the molecular mechanisms underlying these reactions. We aimed to attract readers’ attention to the numerous gaps of knowledge present in the reviewed field and the essential irrelevance between the findings originating from different sources: clinical observations and in vitro mechanistic and molecular studies, as well as preclinical experiments involving animal models. Overall, such inconsistencies make it currently impossible to give a reliable opinion on the action of melatonin on the metabolism of lipoproteins.

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Effects of melatonin administration on mental health parameters, metabolic and genetic profiles in women with polycystic ovary syndrome: A randomized, double-blind, placebo-controlled trial

Cited by 62 publications

References 40 publications

Effects of melatonin on insulin signaling and inflammatory pathways of rats with apical periodontitis

Effects of melatonin on insulin signaling and inflammatory pathways of rats with apical periodontitis

Pathogenesis and Consequences of Disordered Sleep in PCOS

The Mystery behind the Pineal Gland: Melatonin Affects the Metabolism of Cholesterol

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