The effects of a novel combination of selenium and probiotic on weight loss, glycemic control and markers of cardio-metabolic risk in women with polycystic ovary syndrome

Selenium and Polycystic Ovary Syndrome; Current Knowledge and Future Directions: A Systematic Review

“…Therefore, until the results of additional investigations become available, the use of Se supplements in these patients need to warrant more caution. Similarly, Shabani [12] and Jamilian [20] did not observe any effect of Se supplement on FBG levels. Some investigators, however, indicated that a 3-month Se supplementation in subjects with T2DM significantly decreased fasting plasma glucose (FPG) levels indicating that Se supplementation may lead to reduced insulin resistance.…”

“…creased body weight and markers of cardio-metabolic risk [12]. However, another study reported that supplementation with 200 μg of Se daily for 8 weeks did not significantly affect the BMI and weight [22].…”

“…In a study by Jamilian et al [20], it was observed that oral supplementation of 200 μg/day of Se for 8 weeks led to a significant improvement in insulin sensitivity characterized by an increase in quantitative insulin sensitivity check index (QUICKI) and decreases in homeostasis model of assessment-insulin resistance (HOMA-IR) and serum insulin levels. Similarly, Shabani et al [12] stated that 200 μg/day Se plus 8 × 10 CFU/day probiotic supplements in women with PCOS had beneficial effects on improved insulin metabolism, but did not affect FPG levels. On the contrary, Hosseinzadeh et al [19] indicated that administration of 200 μg of Se as a Se-enriched yeast tablet for 12 weeks in women with PCOS did not yield any effect on fasting blood sugar (FBS).…”

“…Characteristics and the main outcomes of the 10 articles [12][13][14][15][16][17][18][19][20][21] included in the systematic review are summarized in ▶Table 1. The trials were published between 2013 and 2018.…”

“…Of all the identified studies, six studies were conducted in Iran. five studies [12,16,19,20,22] used a randomized clinical trial design, whereas the others used a case-control design. All of the five trials used 200 μg Se o r a l l y.…”