Objective: The present work focus in the direction of “Development and evaluation of Ciprofloxacin Hydrochloride loaded ocular insert by using “plantago ovata” as natural polymer”. The current work was carried out to evaluate the control release profile of ocular insert. Natural polymer in ocular insert was used for studying the long acting property. Natural polymer is also used to enhance the bioavailability of drug and reduce toxicity. It is also used to increase the duration of action of drug for prolongs action and gives better in vitro performance as compare than to the conventional ocular formulation.Methods: Solvent casting method was used in the formulation of Ciprofloxacin Hydrochloride loaded ocular inserts. Different ocular insert formulations of varying polymer concentration were prepared. Ocular insert formulation H-1 to H-3 was prepared by using different concentration of HPMC and formulation P-1 to P-4 was prepared by using different concentration of Plantago Ovata.Results: The ocular inserts formulation was within the acceptable limits. All the pre formulation parameters of polymers such as derived properties, compressibility index, Hausner’s ratio, viscosity, melting point, swelling ratio, loss on drying, PH of mucilage solution and pre formulation of active pharmaceutical ingredient such as estimation of drug by using UV spectroscopy, determination of melting point, solubility, partition coefficient and FTIR for compatibility study of drug and excipient were evaluation. FTIR analysis also confirmed no drug-excipient interaction.Conclusion: Prepared inserts in the present study were semitransparent. The mixing of the drug in to the polymer is uniform, due to this; the drug content of all formulation is good. Formulation P4 was selected because it showed better release profile, drug content and other physicochemical properties than other formulated batch when compare. All the prepared inserts showed in vitro drug release for the period of 4 h as compare to the marketed formulation. An in vitro drug release study revealed that ocular formulation gives a prolong action. The formulation was found to be long acting.
Objectives: Natural products are greatly acknowledged for antioxidant and hepatoprotective effects. Vanillin has been studied for radical scavenging effect. The aim of this study was to examine hepatoprotective effect of vanillin against isoniazid and rifampicin induced liver damage in rats. Methods: Wistar rats were used in present study. All the animals study protocols were duly approved by Institutional Animal Ethics Committee of the Institute. Hepatotoxicity was induced by administration of against isoniazid (50 mg/kg) and rifampicin (100 mg/kg) for 14 days. Vanillin was used in the dose of 50, 100 and 200 mg/kg body weight. At the end of study blood was collected and biochemical studies were performed to assess antioxidant status. Results: Oral administration of vanillin at test doses (50, 100 and 200 mg/ kg body weight) resulted in restoration of AST, ALT and ALP. There was a notable decrease in production of SOD and catalase. Conclusion: In the present study, vanillin demonstrated a notable hepatoprotective effect. The protective efficacy of vanillin is possibly because of radical scavenging and antioxidant property.
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