Evaluation of Hepatoprotective Effect of Vanillin in Isoniazid-Rifampicin Induced Hepatocellular Damage

Abstract

Objectives: Natural products are greatly acknowledged for antioxidant and hepatoprotective effects. Vanillin has been studied for radical scavenging effect. The aim of this study was to examine hepatoprotective effect of vanillin against isoniazid and rifampicin induced liver damage in rats. Methods: Wistar rats were used in present study. All the animals study protocols were duly approved by Institutional Animal Ethics Committee of the Institute. Hepatotoxicity was induced by administration of against isoniazid (50 mg/kg) and rifampicin (100 mg/kg) for 14 days. Vanillin was used in the dose of 50, 100 and 200 mg/kg body weight. At the end of study blood was collected and biochemical studies were performed to assess antioxidant status. Results: Oral administration of vanillin at test doses (50, 100 and 200 mg/ kg body weight) resulted in restoration of AST, ALT and ALP. There was a notable decrease in production of SOD and catalase. Conclusion: In the present study, vanillin demonstrated a notable hepatoprotective effect. The protective efficacy of vanillin is possibly because of radical scavenging and antioxidant property.

Formulation, Molecular Charge Topography, and Nosocomial Anti-Infectious Potential of Ruthenium Carbonyl Complex of N-o-Hydroxyacetophenone-Ethylenediamine-N′-o-Vanillin

“…Moreover, the recurrence of important resonating frequencies when compared with the respective Schiff base again stems the successful binding. Similarly, in case of 13 CNMR spectrum, it details the presence of coordinated carbonyl group and also shows the presence of other carbon atoms. For example, 170 ppm is meant for coordinated CO, 161 denotes the resonance of enolic carbon, and the signals at 12 and 48 show the presence of methyl groups [34].…”

“…A feeble 8.2 ppm signal may be assigned for > CH− −N− proton, 3.8 ppm for −OCH 3 and remaining methyl groups around 2.5 ppm. Similarly, 13 S4. Figure 1 shows the proposed 2D structure of the compounds in the present investigation along with the structure of the ligand [19,20,27].…”

“…Both o-vanillin and o-hydroxyacetophenone compounds possess medicinal and industrial significance. o-Vanillin shows effective therapeutic relevance [12,13]. The hydroxyl composition in this type of ligand favors efficient insecticidal behavior that has been evaluated at both the experimental and theoretical levels [14].…”