Although the success rates appeared to be high, the high number of patients who required multiple systemic agents emphasized the fact that localized forms of psoriasis were resistant to therapy.

Psoriasis is a chronic, inflammatory skin disease present in about 3% of the world’s population. The clinical symptoms manifest diversely, therefore one can distinguish several subtypes of psoriasis. The majority of patients with psoriasis experience pruritus, which is an unpleasant sensation that decreases patients’ quality of life. The knowledge on pruritus in different subtypes of psoriasis is limited. We have performed a cross-sectional, prospective, and multicenter study to evaluate the relationship between clinical subtypes of psoriasis (large-plaque, nummular, guttate, palmoplantar, inverse, erythrodermic, palmoplantar pustular, generalized pustular psoriasis, and psoriasis of the scalp) and the prevalence, intensity, and clinical manifestation of itch. We introduced a questionnaire assessing various aspects of pruritus to a total of 254 patients. Out of these, 42 were excluded. Pruritus was present in 92.9% of the remaining patients and its prevalence did not depend on the clinical subtype. A correlation between the severity of psoriasis and the intensity of itch was explicitly noticeable in palmoplantar pustular psoriasis and scalp psoriasis (p < 0.05). The itch sensation was individual and differed among subtypes of psoriasis. In conclusion, pruritus is a frequent phenomenon, and its presentation is different in various subtypes of psoriasis.

Introduction: Acne vulgaris is a multifactorial disease. One of the main factors that plays a role in acne pathogenesis is an increase in sebum secretion. For sebum secretion, sebocyte differentiation followed by sebogenesis is essential. Sebocyte differentiation and proliferation, and sebum synthesis are controlled by complex pathways. Studies have shown that perilipin 2 and melanocortin 5 receptors play a role in sebogenesis. This study sought to determine whether levels of perilipin 2 and melanocortin 5 receptors have an impact on the development of acne vulgaris. Methods: A total of 65 patients diagnosed with acne and 43 healthy control subjects were included in the study. Perilipin 2 and melanocortin 5 receptor levels were analyzed using the enzyme-linked immunosorbent assay (ELISA) technique. Results: No significant differences were observed between the acne group and the control group in serum perilipin 2 (p = 0.594) and melanocortin 5 receptor (p = 0.213) levels. In the moderate acne group, perilipin 2 and melanocortin 5 receptor levels were significantly higher than in the mild acne group (p = 0.0014, p = 0.003). The levels in the severe acne group were not higher compared to the moderate and mild acne groups. Conclusions: This study failed to detect any association between acne pathogenesis and perilipin 2 and melanocortin 5 receptor serum levels. However, these proteins may have an influence on acne severity.

The results of this study provide evidence that both calcipotriol and MPA decrease the p53 and ki-67 expression and increase bcl-2 expression. However, it should further be elucidated if these changes were the common behaviour of psoriatic keratinocytes to any antipsoriatic medication.

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