The effects of calcipotriol and methylprednisolone aseponate on bcl‐2, p53 and ki‐67 expression in psoriasis

Adışen, Esra; Gülekon, Ayla; Erdem, Opdr; Dursun, Ayberk; Gürer, Mehmet Ali

doi:10.1111/j.1468-3083.2006.01508.x

Cited by 17 publications

(20 citation statements)

References 30 publications

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“…Simultaneously, the complex preparation, containing calcipotriol and betamethasone, contributed to a decrease in Ki-67 antigen expression by 5% at week 4 and by 74% at week 6 of the treatment [29]. According to Adişen et al, after six-week therapy with calcipotriol, the Ki-67 antigen expression, which was high before, significantly decreased [30]. Similar findings were observed with regards to methylprednisolone aceponate.…”

Section: Discussionmentioning

confidence: 59%

Influence of phototherapy in psoriasis on ki-67 antigen expression: a preliminary study

Jesionek-Kupnicka

Chomiczewska-Skóra²,

Rotsztejn³

2013

pjp

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Antigen Ki-67 is a non-histone nuclear protein, closely connected with cell proliferation. Determining Ki-67 allows for a quick and reliable evaluation of the growth fraction of the studied cell population. It serves as a marker of proliferative activity in neoplasms and other diseases with excessive cell proliferation such as psoriasis. Evaluation of Ki-67 expression in epidermal cells was performed in 10 individuals suffering from plaque psoriasis, before and after one of three methods of phototherapy: broadband UVB, narrowband UVB or PUVA. We observed increased Ki-67 antigen expression in psoriatic lesions. The percentage of Ki-67 positive nuclei in the epidermis affected by the disease ranged from 0 to 30% and in the macroscopically healthy surrounding tissue the percentage was from 0 to 10%. After phototherapy the expression in lesional skin decreased (p < 0.01). The greatest decrease was observed after the application of PUVA therapy (from 25 to 10% of cells, p < 0.05). No significant differences were observed in the perilesional skin with regard to Ki-67 antigen expression before or after phototherapy. On the basis of our own study and studies conducted by other researchers, it can be concluded that reduced Ki-67 expression after the application of PUVA and UVB therapies in the psoriatic epidermis is not a characteristic result of phototherapy only. It is a characteristic property of any effective psoriasis therapy.

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Section: Discussionmentioning

confidence: 59%

Influence of phototherapy in psoriasis on ki-67 antigen expression: a preliminary study

Jesionek-Kupnicka

Chomiczewska-Skóra²,

Rotsztejn³

2013

pjp

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“…4 Ki-67 is an established marker of cell proliferation. 6 It is highly expressed in psoriasis and correlated with the clinical severity of disease. 6 It is highly expressed in psoriasis and correlated with the clinical severity of disease.…”

Section: Introductionmentioning

confidence: 99%

Immunohistochemical Expression of GLUT-1 and Ki-67 in Chronic Plaque Psoriasis

Abdou¹,

Maraee

Eltahmoudy³

et al. 2013

The American Journal of Dermatopathology

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Many inflammatory mediators and other biological markers are upregulated in psoriatic lesions; some of these alterations also persist in nonlesional skin. Glucose is the major source of energy for cells, and glucose transporter 1 is the most common glucose transporter in humans (GLUT-1). The present study aimed at evaluating the pattern of expression of GLUT-1 and Ki-67 in psoriatic skin (involved and uninvolved) and correlating their expression with the clinicopathological parameters in the studied patients. This study was carried out on 30 patients presented with chronic plaque psoriasis and 10 apparently healthy volunteers as a control group. GLUT-1 was not expressed in epidermis of normal skin, whereas it was expressed in 76.6% of uninvolved and 86.7% of involved skin of psoriatic patients, where both the latter differed significantly regarding the intensity (P = 0.001) and localization (P = 0.001) of GLUT-1 expression. The percentage of Ki-67 expression did not differ significantly between involved and uninvolved skin of psoriatic patients, but they were higher than that of normal skin of control group. Nucleolar pattern of Ki-67 expression was significantly associated with male sex (P = 0.05), marked parakeratosis (P = 0.01), and marked angiogenesis (P = 0.05). GLUT-1 expression was associated with degree of acanthosis and percentage of Ki-67 expression. From this study, GLUT-1 is upregulated in psoriatic epidermis and may be involved in facilitation of keratinocyte proliferation in psoriasis. Nucleolar pattern of Ki-67 is an indicator of progressive keratinocyte proliferation in psoriasis.

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“…For cell proliferation, Ki‐67 protein is required, and it is used as a proliferation indicator. Cells expressing Ki‐67 in normal skin are 1–3% and are mostly found in the basal and suprabasal layers . The high level of Ki‐67 in oral LP confirms that it may possibly have a secondary proliferative disorder due to the cyclic fragmentation of cells leading to proliferation .…”

Section: Discussionmentioning

confidence: 86%

“…Keratinocytes in the superficial epidermis regulate or stabilize the proliferation of basal cells. Furthermore, physiological apoptosis has been demonstrated in the germinative region of the nonpathogenic epidermis . Apoptotic keratinocytes can be seen in diseases such as psoriasis and LP .…”

Section: Discussionmentioning

confidence: 99%

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Immunohistochemical evaluation of the effect of acitretin and systemic steroid treatments on Ki‐67, Bcl‐2, and COX‐2 levels in cutaneous lichen planus patients

Öztürk

Yavuz

et al. 2019

Int J Dermatology

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Background Lichen planus (LP) is an inflammatory disease that affects skin, hair follicles, mucous membranes, and nails. Ki‐67 is an antigen associated with the proliferation of cells in all stages of cell cycle except G0. Bcl‐2 is a protooncogene that protects cells from apoptosis. COX‐2 is an antiapoptotic protein that increases in inflammation. The infiltration of T cells in LP seems to be responsible in the apoptosis of the basal keratinocytes. Objective The purpose of this study was to investigate the effects of prednisolone and acitretin treatments on Ki‐67, Bcl‐2, and COX‐2 expression and apoptosis in patients with LP and the role of Ki‐67, Bcl‐2, and COX‐2 proteins in LP. Methods Fifty‐eight patients with clinically and histopathologically diagnosed LP who had not been treated with systemic treatment before and 15 healthy volunteers were evaluated prospectively. Pretreatment and posttreatment biopsies were immunohistochemically stained with Ki‐67, Bcl‐2, and COX‐2. The percentage of the stained cells were calculated and recorded. Results Although the percentage of staining with Ki‐67 and Bcl‐2 after treatment with prednisolone and acitretin decreased significantly (P < 0.05) in both groups, there was no significant difference between groups (P > 0.05). COX‐2 decreased but was not statistically significant. Conclusions With this study in cutaneous lichen planus, prednisolone and acitretin treatments reduced Bcl‐2 and Ki‐67 levels and did not effect COX‐2 levels. It should be clarified whether these results can be obtained with any treatment effective in cutaneous lichen planus.

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The effects of calcipotriol and methylprednisolone aseponate on bcl‐2, p53 and ki‐67 expression in psoriasis

Abstract: The results of this study provide evidence that both calcipotriol and MPA decrease the p53 and ki-67 expression and increase bcl-2 expression. However, it should further be elucidated if these changes were the common behaviour of psoriatic keratinocytes to any antipsoriatic medication.

Cited by 17 publications

References 30 publications

Influence of phototherapy in psoriasis on ki-67 antigen expression: a preliminary study

Influence of phototherapy in psoriasis on ki-67 antigen expression: a preliminary study

Immunohistochemical Expression of GLUT-1 and Ki-67 in Chronic Plaque Psoriasis

Immunohistochemical evaluation of the effect of acitretin and systemic steroid treatments on Ki‐67, Bcl‐2, and COX‐2 levels in cutaneous lichen planus patients

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