Evaluation of perilipin 2 and melanocortin 5 receptor serum levels with sebogenesis in acne vulgaris patients

Abstract

Introduction: Acne vulgaris is a multifactorial disease. One of the main factors that plays a role in acne pathogenesis is an increase in sebum secretion. For sebum secretion, sebocyte differentiation followed by sebogenesis is essential. Sebocyte differentiation and proliferation, and sebum synthesis are controlled by complex pathways. Studies have shown that perilipin 2 and melanocortin 5 receptors play a role in sebogenesis. This study sought to determine whether levels of perilipin 2 and melanocortin 5 receptors have an impact on the development of acne vulgaris. Methods: A total of 65 patients diagnosed with acne and 43 healthy control subjects were included in the study. Perilipin 2 and melanocortin 5 receptor levels were analyzed using the enzyme-linked immunosorbent assay (ELISA) technique. Results: No significant differences were observed between the acne group and the control group in serum perilipin 2 (p = 0.594) and melanocortin 5 receptor (p = 0.213) levels. In the moderate acne group, perilipin 2 and melanocortin 5 receptor levels were significantly higher than in the mild acne group (p = 0.0014, p = 0.003). The levels in the severe acne group were not higher compared to the moderate and mild acne groups. Conclusions: This study failed to detect any association between acne pathogenesis and perilipin 2 and melanocortin 5 receptor serum levels. However, these proteins may have an influence on acne severity.

Proopiomelanocortin (POMC) and psychodermatology

“…64 It is noteworthy that the effects of psychosocial stress were not studied within the acne groups in this study. 64 Also, the proteins were being measured indirectly from blood samples, rather than from a skin sample and the sample sizes involved in the study were rather small. 64 1.8 | Alopecia, the HPA axis and psychodermatology CRF is recognized as an inhibitor of hair shaft production and it also is important in the premature stimulation of the catagen phase.…”

“…64 Also, the proteins were being measured indirectly from blood samples, rather than from a skin sample and the sample sizes involved in the study were rather small. 64 1.8 | Alopecia, the HPA axis and psychodermatology CRF is recognized as an inhibitor of hair shaft production and it also is important in the premature stimulation of the catagen phase. 65 CRF also has an influence on the reduction in the increase of keratinocytes in the hair matrix and the induction of their apoptosis.…”

“…Against this argument of MC5‐R involvement in acne is a more recent study 64 . Acne vulgaris is a multifactorial disease 61,64 .…”

“…Against this argument of MC5‐R involvement in acne is a more recent study 64 . Acne vulgaris is a multifactorial disease 61,64 . One of the main aspects that acts to influence acne pathogenesis is elevated sebum secretion 61,64 .…”

Melanocortin-5 Receptor: Pharmacology and Its Regulation of Energy Metabolism

“…In contrast to MC3R and MC4R, studies on MC5R are very limited [ 41 , 42 , 43 , 44 , 45 , 47 , 48 , 49 , 50 , 63 , 64 , 65 , 66 ]. Moreover, the role of MC5R in energy metabolism has been rarely investigated.…”