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Background: COVID-19 is an infectious disease caused by a newly identified strain of coronavirus (SARS-CoV-2). This strain is responsible for respiratory infections in humans. Objective: The objective of this study was to analyze the clinical efficacy and safety of convalescent plasma (CP) therapy in coronavirus disease 2019 (COVID-19) cases. Methodology: This was an experimental trial of COVID-19 patients treated with convalescent plasma (CP) therapy, these patients were admitted in Lahore General Hospital, Lahore, Pakistan during April 24 to august 24, 2021. Results: Pearson correlation was applied to extract the efficacy of convalescent plasma therapy (CP). A p-value ≤0.05 was considered significant. 16 out of 20 patients (80%) were completely recovered from COVID-19. Conclusion: Convalescent plasma (CP) proved to be an effective and safe therapy for confirmed cases of COVID-19. However, two critically ill patients died.

Objective: In this study the effects of carbonated drinks on the healing process of oral submucosa of albino wistar rats were evaluated. Design: This study comprised of 24 adult albino wistar rats which were randomly assigned to a experimental group 1 and an experimental group 2. A circular wound of 3.0 mm was created on the buccal mucosa of each albino wistar rat at day 0. Animals in control group were fed with chow pellet and water while those in experimental group were fed with chow pellet and a commercially available carbonated drink instead of water. 6 animals from each group were sacrificed by decapitation under deep anesthesia at day 7 and 21. The tissue dissected from buccal area was serially sectioned and stained with Haematoxylin & Eosin stains. Wound site was histologically assessed for differences in the healing pattern of submucosa; inflammatory cell count and neovascularization between two groups. Results: There was a marked difference in the healing pattern between the two groups. Animals in group-1 showed a normal healing pattern with formation of a fibrous connective tissue at the end of day-21. In the group-2, there is altered healing phenomenon at the end of the experiment with a subsequent delayed inflammatory reaction at day-21 Conclusion: These findings suggest that consumption of carbonated drinks can disrupt oral wound healing. The contents in carbonated drinks have a proinflammatory action on the soft tissue.