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We report an autopsy case of an 82-year-old woman with progressive dementia due to miliary brain metastasis from lung adenocarcinoma. The patient presented with dementia 5 months prior to death and suddenly died of pulmonary hemorrhage. Postmortem examination revealed normal appearance of the brain. However, there were numerous foci of cancer metastasis in all parts of the brain on light microscopic examination. The carcinoma cells were located in the perivascular (Virchow-Robin) space and did not invade to the brain parenchyma. The carcinoma cells were also found in the subpial space. In the cerebral cortex, foci of metastasis appeared to spread in the following way: tiny foci of metastasis initially occur in the middle cortical layer, then spread to all layers through the perivascular space, and finally reach the subpial space and subcortical white matter. Although the junction between gray and white matter is a preferred site for usual brain metastasis, middle cortical layer was considered to be the initial site for metastasis in our patient. The perivascular pial sheath plays an important role for the development of miliary brain metastasis.

Mycobacterium kyorinense sp. nov., a novel, slow-growing species, related to Mycobacterium celatum, isolated from human clinical specimens A novel, non-pigmented, slow-growing mycobacterium was identified on the basis of biochemical and nucleic acid analyses, as well as growth characteristics. Three isolates were cultured from clinical samples (two from sputum and one from pus in lymph nodes) obtained from three immunocompetent patients with infections. Bacterial growth occurred at 28-42 6C on Middlebrook 7H11-OADC agar. The isolates showed negative results for Tween hydrolysis, nitrate reductase, semiquantitative catalase, urease activity, 3 day arylsulfatase activity, pyrazinamidase, tellurite reduction and niacin accumulation tests, but positive results for 14 day arylsulfatase activity and heat-stable catalase tests. The isolates contained a-, keto-, and dicarboxymycolates in their cell walls. Sequence analysis revealed that all isolates had identical, unique 16S rRNA sequences. Phylogenetic analysis of the 16S rRNA, rpoB, hsp65 and sodA gene sequences confirmed that these isolates are unique but closely related to Mycobacterium celatum. DNA-DNA hybridization of the isolates demonstrated less than 50 % reassociation with M. celatum and Mycobacterium branderi. On the basis of these findings, a novel species designated Mycobacterium kyorinense sp. nov. is proposed. The type strain is KUM 060204 T (5JCM 15038 T 5DSM 45166 T ).The GenBank/EMBL/DDBJ accession numbers for the 16S rRNA, hsp65, proB and sodA gene sequences of strains KUM 060204 T , NTH 512-121 and AHM 060905 are, respectively: AB370111, AB370169 and AB370170 (16S rRNA); AB370171, AB370176, and AB370177 (hsp65); AB370178, AB370182, and AB370183 (rpoB); AB370184, AB370188, and AB370189 (sodA).

by the change in the angle-bending force constant F, in the valence-force potential model; this constant governs the frequency of the transverseacoustic mode X, . With reference to the ratios mentioned above, it should be noted that the differences between the dimensionless frequencies Ox conform to a closely similar pattern, the ra-. 3 tio being 8. 8: 1:1. 7. ACKNOWLEDGMENT The authors are indebted to Dr. J. M. Rowe for valuable discu. ssions on the present work.Reflectivity spectra of ZnSe"Te~"single crystals were measured from 2. 0 to 6.6 eV through the whole range of mole fraction x at room temperature.The variation of the band gaps such as the Eo, eg, E&, and E2 with x is reported. The Eo, e~, and E~gaps exhibit spin-orbit splitting. The lowest gap Eo shows a minimum in energy at x =0.33, The minimum value is 2. 13 eV.