Erlotinib failed to show an improvement in PFS or OS compared with docetaxel in an EGFR-unselected patient population.

Optical conductivity data of the intermetallic compounds (Fe1-xVx)3Al ( 0

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Polarized reflectivity spectra of single crystals of ␣-PbF 2 , ␤-PbF 2 , PbCl 2 , and PbBr 2 have been measured at 10 K in the energy range up to 30 eV using synchrotron radiation as a light source. The spectra are well resolved in comparison with those reported previously. Optical constants have been derived through the Kramers-Kronig analysis. The effect of phase transition on the optical spectra of PbF 2 is also examined. With use of the discrete variational X␣ method, the electronic structures of the clusters consisting of a Pb 2ϩ ion and neighboring halogen ions have been calculated for better understanding of the optical properties of Pb halides. The calculation indicates that the lowest excitons in all lead halides are attributed to the cationic transitions. The electronic structures of lead halides are discussed on the basis of a comparison of experiment and calculation.

A series of tetrahydronaphthyridine derivatives as novel RORγt inverse agonists were designed and synthesized. We reduced the lipophilicity of tetrahydroisoquinoline compound 1 by replacement of the trimethylsilyl group and SBDD-guided scaffold exchange, which successfully afforded compound 7 with a lower log  D value and tolerable in vitro activity. Consideration of LLE values in the subsequent optimization of the carboxylate tether led to the discovery of [ cis-3-({(5 R)-5-[(7-fluoro-1,1-dimethyl-2,3-dihydro-1 H-inden-5-yl)carbamoyl]-2-methoxy-7,8-dihydro-1,6-naphthyridin-6(5 H)-yl}carbonyl)cyclobutyl]acetic acid, TAK-828F (10), which showed potent RORγt inverse agonistic activity, excellent selectivity against other ROR isoforms and nuclear receptors, and a good pharmacokinetic profile. In animal studies, oral administration of compound 10 exhibited robust and dose-dependent inhibition of IL-17A cytokine expression in a mouse IL23-induced gene expression assay. Furthermore, development of clinical symptoms in a mouse experimental autoimmune encephalomyelitis model was significantly reduced. Compound 10 was selected as a clinical compound for the treatment of Th17-driven autoimmune diseases.

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