Obat merupakan komoditas yang memiliki banyak manfaat, namun juga dapat memberikan dampak negatif jika tidak dikelola dengan baik. Salah satu dampak negatifnya adalah obat sisa yang sudah tidak digunakan oleh masyarakat akan menjadi sampah B3 rumah tangga yang membahayakan lingkungan hidup. Mengingat dampak kesehatan dan lingkungan yang cukup besar terkait obat sisa, peneliti melakukan penelitian terkait pengelolaan obat yang tidak terpakai dalam skala rumah tangga. Metode yang digunakan dalam penelitian ini adalah dengan menggunakan metode penelitian analisis kuantitatif. Data diperoleh melalui teknik wawancara menggunakan instrumen berupa kuesioner kepada responden sebanyak 100 (seratus) rumah tangga di Kota Bandung yang dipilih melalui cluster random sampling. Hasil penelitian menunjukkan 86,0% rumah tangga memiliki obat di rumah yang diperoleh dari fasilitas kesehatan (rumah sakit, klinik, dan puskesmas) (39%) dan apotek (38%). Sebanyak 25,53% dari obat yang dimiliki tidak lagi digunakan dan didominasi oleh golongan analgesik-antipiretik (6,28%) dan obat batuk dan flu (6,69%). Hampir seluruh responden di Kota Bandung (93%) membuang obat yang tidak lagi digunakan ke tempat sampah tanpa prosedur yang tepat dan sisanya membuang ke saluran air, dikubur, atau dibakar. Hal ini menunjukkan potensi resiko pencemaran lingkungan yang tinggi dan timbulnya dampak negatif lain dari segi sosial, ekonomi, dan kesehatan.
Thalassemia major (TM) is an inherited disease caused by defective or absent of hemoglobin chain synthesis. Regular chelation therapy is necessary to reduce excess iron in several organs of TM patients. The most commonly used chelating agents are deferasirox and deferiprone. However, information regarding their effectiveness and side effects in Indonesian children population with TM were limited. This study was conducted to assess the effectiveness and side effects of deferasirox and deferiprone in pediatric patients with TM. This was an observational study with prospective analysis which was conducted during April-August 2015. We included pediatric patients with TM who visited a hospital in Bandung, Indonesia, using consecutive sampling method. Thirty two subjects were divided into two groups, i.e., deferasirox and deferiprone group. Review of medical records and interview were performed for each participants. Effectiveness was defined as reduction in ferritin level. Side effects were assessed using Naranjo scale. Data were analyzed using Mann-Whitney test, Wiloxon test and Chi square test. P value < 0.05 defined statistical significance. We found that deferasirox was more effective than deferiprone for the treatment of TM in pediatric patiens, with less side effects. The use of deferasirox as iron chelating agent is recommended for patients with TM.
Introduction: Type 2 diabetes mellitus consists of an array of dysfunction characterized by hyperglycemia. The activity of smooth pigweed (Amaranthus hybridus L.) leaves water extract on male Wistar rats. Objectives: This research was started by supplying simplicia, making smooth pigweed leaves water extract, and testing the hypoglycemic activity of smooth pigweed leaves water extract on male Wistar rats. Methods: The glucose tolerance method was used to determine the hypoglycemic activity of smooth pigweed leaves water extract. Male white rats were divided into five groups of six rats each: a positive control group (0.5% of tragacanth suspension), a comparison group (Diabinese suspension at a dose of 22.5 mg/kg body weight (bw)), and three test groups at doses of 50 mg/kg bw, 100 mg/kg bw, and 150 mg/kg bw. Results and conclusions: The most significant hypoglycemic activity was seen with the dose of 150 mg/kg bw in comparison with the control group at 90 minutes.
Penyimpanan merupakan tindakan menyimpan dan mengamankan obat-obatan di tempat yang terlindung. Mutu obat penting untuk dipertahankan melalui penyimpanan. Ketidakefektifan obat dapat disebabkan oleh sistem penyimpanan yang tidak tepat. Tujuan penelitian adalah untuk mengevaluasi sistem penyimpanan obat di Apotek Bandung. Metode penelitian yang digunakan adalah metode observasi deskriptif, dan evaluasi dilakukan dengan mengamati kegiatan yang ada di apotek. Hasil penelitian menunjukkan bahwa sistem penyimpanan obat di salah satu apotek di Kota Bandung, telah sesuai dengan Peraturan Menteri Kesehatan Republik Indonesia No. 73 Tahun 2016 tentang Standar Pelayanan Kefarmasian di Apotek yaitu sebesar 80% yang mana nilai tersebut masuk kedalam kriteria penyimpanan yang “Baik”.
Thalassemia major (TM) is an inherited disease caused by defective or absent of hemoglobin chain synthesis. Regular chelation therapy is necessary to reduce excess iron in several organs of TM patients. The most commonly used chelating agents are deferasirox and deferiprone. However, information regarding their effectiveness and side effects in Indonesian children population with TM were limited. This study was conducted to assess the effectiveness and side effects of deferasirox and deferiprone in pediatric patients with TM. This was an observational study with prospective analysis which was conducted during April-August 2015. We included pediatric patients with TM who visited a hospital in Bandung, Indonesia, using consecutive sampling method. Thirty two subjects were divided into two groups, i.e., deferasirox and deferiprone group. Review of medical records and interview were performed for each participants. Effectiveness was defined as reduction in ferritin level. Side effects were assessed using Naranjo scale. Data were analyzed using Mann-Whitney test, Wiloxon test and Chi square test. P value < 0.05 defined statistical significance. We found that deferasirox was more effective than deferiprone for the treatment of TM in pediatric patiens, with less side effects. The use of deferasirox as iron chelating agent is recommended for patients with TM.
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