Hypoglycemic activity test on smooth pigweed (Ammaranthus Hybridus L) leaf water extract on male Wistar rats

Abstract

Introduction: Type 2 diabetes mellitus consists of an array of dysfunction characterized by hyperglycemia. The activity of smooth pigweed (Amaranthus hybridus L.) leaves water extract on male Wistar rats. Objectives: This research was started by supplying simplicia, making smooth pigweed leaves water extract, and testing the hypoglycemic activity of smooth pigweed leaves water extract on male Wistar rats. Methods: The glucose tolerance method was used to determine the hypoglycemic activity of smooth pigweed leaves water extract. Male white rats were divided into five groups of six rats each: a positive control group (0.5% of tragacanth suspension), a comparison group (Diabinese suspension at a dose of 22.5 mg/kg body weight (bw)), and three test groups at doses of 50 mg/kg bw, 100 mg/kg bw, and 150 mg/kg bw. Results and conclusions: The most significant hypoglycemic activity was seen with the dose of 150 mg/kg bw in comparison with the control group at 90 minutes.