Antimicrobial and phytochemical properties of the crude extract of some selected plant samples against some microbial isolates was investigated.Plant samples were extracted using ethyl acetate and methanol as extracting solvents based on polarity. Antimicrobial studies was carried out using Agar disc diffusion method. Zones of inhibitions were measured, Tetracycline, Ampicillin, Chloramphenicol and Ofloxacin antibiotics were used as positive control. Extracting solvent served as negative control and work was done in triplicates.Plant samples were found to contain several bioactive compounds in various combinations. Ethyl acetate Pawpaw leaves extract gave the best results with zones of inhibition as high as 27.3 ± 11.7mm and 25.3 ± 0.6mm against Escherichia coli and Candida albicans respectively, while methanol Pawpaw leaves extracts gave the best result with zone of inhibition as high as 25.0 ± 13.0mm against Staphylococcus aureus. Ampicillin and Chloramphenicol in all cases and for both extracting solvents showed no significant difference in the mean zone of inhibition compared with plant extracts at 5% level of significance. The minimum bactericidal concentration was found with ethyl acetate pawpaw leaves extract against Escherichia coli and Pseudomonas aeruginosa (bactericidal) at 100mg/ml and 200mg/ml respectively while all the others were bacteriostatic.It was thus concluded that the selected plant extracts could serve as alternative drugs for the treatment of diseases.
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