A novel modified carbon paste electrode (CPE) based on an MnO2‐TiO2 nanocomposite and 2‐(3,4 dihydroxyphenethyl) isoindoline‐1,3‐dione (DPID) as the modifier for the simultaneous analysis of cysteine (Cys), tryptophan (Trp) and uric acid (UA), as three key biochemicals present in human body. The MnO2/TiO2 nanocomposite was synthesized through a chemical co‐precipitation approach and the resulting electrode (MnO2‐TiO2/DPID/CPE) was used for studying the electrochemical oxidation of cysteine (Cys), tryptophan (Trp) and uric acid. As opposed to conventional CPEs, the oxidation peak potential of cysteine on MnO2‐TiO2/DPID/CPE had a 600.0 mV decrease in overpotential and could be observed at 30.0 mV, and the signals were linear from 0.025 to 200.0 μM, and a lower detection limit of 0.013 μM was reached. The MnO2‐TiO2/DPID/CPE was satisfactorily used for the concurrent analysis of Cys, Trp and UA in pharmaceutical and biological samples.
A high selective sensor based on carbon paste electrode chemically modified with MgO nanoparticles (MgO/NPs) and acetylferrocene (AF) was used for the simultaneous determination of N-acetylcysteine (NAC) and folic acid (FA) in aqueous solution. Electrochemical methods such as cyclic voltammetry (CV), chronoamperometry (CHA), and differential pulse voltammetry (DPV) were used to study the ability of proposed sensor for the electrocatalytic oxidation of NAC. On the best condition in voltammetric analysis, the DPV peak current of NAC increased linearly with its concentration in the ranges of 0.005-0.5 µmol L −1 and 1.0-50.0 µmol L −1 . The detection limit (S/N = 3) was 1.0 nmol L −1for NAC. The prepared sensor exhibits good resolution between NAC and FA signals for simulations determination of these compounds.
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