Fabrication of Amplified Nanostructure Based Sensor for Analysis of N-Acetylcysteine in Presence of High Concentration Folic Acid

Abstract

A high selective sensor based on carbon paste electrode chemically modified with MgO nanoparticles (MgO/NPs) and acetylferrocene (AF) was used for the simultaneous determination of N-acetylcysteine (NAC) and folic acid (FA) in aqueous solution. Electrochemical methods such as cyclic voltammetry (CV), chronoamperometry (CHA), and differential pulse voltammetry (DPV) were used to study the ability of proposed sensor for the electrocatalytic oxidation of NAC. On the best condition in voltammetric analysis, the DPV peak current of NAC increased linearly with its concentration in the ranges of 0.005-0.5 µmol L −1 and 1.0-50.0 µmol L −1 . The detection limit (S/N = 3) was 1.0 nmol L −1for NAC. The prepared sensor exhibits good resolution between NAC and FA signals for simulations determination of these compounds.

Electro-catalytic amplified sensor for determination of N-acetylcysteine in the presence of theophylline confirmed by experimental coupled theoretical investigation

“…In addition, N -acetylcysteine is used for the control of lipoprotein and homocysteine levels that are harmful to the human body at high levels 11 . On the other hand, the high consumption of N -acetylcysteine can increase risk of vomiting, nausea, and constipation which is very significant for the investigation of N -acetylcysteine in real samples 12 – 15 .…”

“…Due to their selective response and low-cost, the electrochemical sensors are a better selection compared to other analytical methods for the determination of drugs 17 – 20 . High overvoltage of N -acetylcysteine and theophylline at the bare electrode surface is a major issue for the analysis of this drug at low levels 7 , 12 , 21 . Therefore, modification of electrodes is vital for the investigation of N -acetylcysteine at low levels 22 .…”

A theoretical approach on the ability of functionalized gold nanoparticles for detection of Cd2+

“…Cadmium (Cd) as a toxic element is wildly present in air, soil, and water 12 . The targets of this element are lung, liver, kidney, bone, and immune system 13 .…”

MnO2‐TiO2 Nanocomposite and 2‐(3,4‐Dihydroxyphenethyl) Isoindoline‐1,3‐Dione as an Electrochemical Platform for the Concurrent Determination of Cysteine, Tryptophan and Uric Acid

“…Also Cys usually coexists with different electro-active compounds including Trp and UA, which might have very close or similar oxidation peak potentials, and hence cause serious interfering effects [22] and consequently the electrode materials can play important roles in electroanalytical methods [23][24][25][26] and chemical modification of electrodes can be used as a means to overcome these problems [27][28][29][30][31][32]. Various active materials, including e. g. nanocomposites, metal oxides, graphene and carbon nanotubes, and different mediators have recently been used to enhance electrodes [33][34][35][36][37][38]. As an instance, Raoof et al worked on the determination of N-acetyl-L-cysteine, uric acid and tryptophan through modifying an electrode with a homogeneous electrochemical catalyst, i. e. 4-chlorocatechol [22].…”