Dermatomyositis, a connective tissue disorder, is an idiopathic inflammatory myopathy characterised by skin manifestation. The diagnosis of dermatomyositis is based on rashes on the skin, progressive muscle weakness, elevated serum muscle enzymes, abnormal electromyogram, and abnormal findings on muscle biopsy. Hereby presenting this rare case of a 57-year-old female with dermatomyositis with all the typical clinical findings with interstitial lung disease.
Sickle cell disease (SCD) is an inherited haemoglobinopathy that may present acutely as stroke, vaso-occlusive crisis or acute chest syndrome. Acute conditions require prompt diagnosis and intensive management to prevent morbidity and mortality. Here, we present a case of sickle cell anemia treated with therapeutic red cell exchange that manifested as acute chest syndrome. A 26 year old male who had history of high-grade intermittent fever and cough with expectoration was diagnosed as pneumonia and put on antibiotics. Peripheral smear showed sickle cells and HPLC showed HbS of 67%. we made a diagnosis of sickle cell anemia with acute chest syndrome. We treated the patient with therapeutic red cell exchange following which HbS reduced to 24% from the initial 67%. We observed significant clinical improvement suggesting red cell exchange as a useful therapeutic option for acute sickle cell anaemia.
introduction: Pulmonary embolism is a potentially lethal condition that is frequently underdiagnosed. The severity and clinical presentation of PE are variable, hence clinching the correct diagnosis is difficult. Prompt diagnosis of PE is essential to reduce morbidity and mortality. Current research aimed to study the clinical characteristics, risk factors and clinical outcomes of patients diagnosed with pulmonary thromboembolism. Material and Methods: In this retrospective study data were collected from baseline clinical characteristics, presenting signs and symptoms, results of echocardiography and imaging studies, therapeutic modality and in-hospital course. Results: 52 cases of Pulmonary embolism were reported with an incidence of 0.33%. Male predominance (58%) was noted. Associated comorbid conditions like HT was present in 24 patients and DM was present in15 patients. The most common symptom at presentation was dyspnea (31 patients). The overall mortality rate was 3.8% (2 patients). Conclusion: The outcome of PE is improving; however, it remains an important risk factor for mortality in hospitalized patients.
Sheehan syndrome is a rare complication of post-partum hemorrhage causing post-partum ischemic necrosis of the pituitary gland. It is a disease with declining incidence, more prevalent in developing countries. The incidence of Sheehan syndrome is 1 in 100,000 births. It was first described by a British pathologist Harold Leeming Sheehan in 1937.We present the case of a 42 year old female who presented with bilateral knee pain for 4 years, on over-the-counter steroids. She gave a history of lactational failure and secondary amenorrhea following childbirth. Her investigations revealed central hypothyroidism and she was diagnosed as Sheehan syndrome.
Chronic pancreatitis has a fibro-inflammatory subtype called autoimmune pancreatitis. A combination of imaging tests, including a CT scan and pancreatography, lab tests that check for IgG4 and/or autoantibodies, histological analysis, and a favourable response to corticosteroid treatment are used for diagnosis. Hereby we present a case of a young boy who presented to our hospital with recurrent abdominal pain and on further investigation was found to have elevated levels of IgG4 as well as a developmental abnormality of pancreatic duct known as pancreatic divisum.
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