Much interest has been displayed in the past few years in the effect on human subjects of reduction, or as far as possible, abolition of sensory stimulation, so that virtual isolation from the environment is produced. Recent comprehensive reviews have appeared, dealing with experimental work (Solomon et al. 1957) and conditions arising incidentally in the course of various therapeutic procedures (Grünthal 1957), and it is therefore unnecessary to deal with the topic at length here.

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Although chlorpromazine was the first of the phenothiazine drugs to be used in psychiatry, and has since been the subject of an extensive literature, there is a surprising dearth of information about the nature of its effect in chronic schizophrenia. Some early reports indicated that it produced a beneficial change, but before this could be examined and documented the attention of most psychiatrists was diverted to newer and supposedly more potent analogues. The present trial was undertaken with three factors in mind, which had not been fully taken into account of in previous studies. These were:

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