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Concentrations of the serum markers of apoptosis sFas and M30 and of the marker of total cell death M65 are elevated in patients with immune-mediated liver diseases, whereas activity of DNAse is reduced. In patients with PSC, sICAM, M30 and M65 may serve as indicators for disease activity and prognosis.

Body image, a multidimensional construct, affects women in myriad ways. Existing scholarship has established a relationship between body image and negative mental and sexual health outcomes and suggests that it may also be related to physical health outcomes. The purpose of the study reported in this article was to explore relationships between body appreciation, a multidimensional measure of body image, and self-perceived physical health among a sample of emerging adult women (N = 399). In this sample, body appreciation was positively and significantly related to self-perceived physical health. This study contributes to a growing body of literature on the consequences of body image among women and can be used to inform interventions aimed at improving the well-being of women.

Using the 2018 National Survey on Drug Use and Health, this study examined the US national prevalence rates of suicidal ideation (SI) and suicide attempts (SA) among four demographic adult groups (race-sex, age, education, and marital status) with and without major depressive episode (MDE). The highest prevalence rates of SI for those with and without MDE occurred among adults 18 to 25 years, with some college education, White females and males, and unmarried and never been married. Among the same demographic groups, proportions of SA were also the highest for those with MDE. A Pearson chi-square test confirmed significant associations between MDE and SI and between MDE and SA. The model fit results showed that the four variables were significant predictors of SI and SA (p < 0.05). Serious mental health needs are unmet, especially among adults with depression. Population-based clinical interventions are needed to reduce rates of depression, SI, and SA.

Background: This study examines the national prevalence rates of suicidal ideation and attempts among adults with and without major depressive episode (MDE) in five demographic groups –race, sex, age, education, and marital status – in the United States. Methods: Data extracted from the 2018 National Survey on Drug Use and Health (NSDUH) were analyzed , producing 42,551 records. Wald chi-square diagnostic examination was conducted on the multinomial logistic regression (MLR) model with five demographic predictor variables.Results: The highest rates of suicidal ideation for those with MDE occurred in White females (40.6%), adults 18-25 years old (36.4%), individuals with some college education (40.4%), and unmarried adults (57.1%). For those without MDE, the highest rates of suicidal ideation occurred among White males (31.9%), adults 18-25 years old (31.9%), individuals with some college education (38.7%), and unmarried adults (49.6%). Among the same demographic groups, proportions of suicide attempts were highest for those with MDE. A chi-square test indicated significant differences across adults with and without MDE in all demographic groups. The MLR model fitting results showed that the five demographic variables were significant predictors of suicidal ideation and attempts in both populations (p&lt;0.05).Limitations: Our data are cross-sectional and no directionality or causality can be assumed between study variables. A small proportion of the population was excluded from the survey.Conclusions: serious mental health needs are unmet for many demographic groups, especially among individuals with depression. Population-based clinical interventions are needed to reduce rates of depression, suicidal ideation, and attempts.

The effect of the alcoholic extract of Arbutus andrachne on certain biochemical parameters and the histology of the visceral organs in nonpregnant adult female rats was studied. The lethal dose 50% (LD) 50 was estimated, and three different doses (1/10th , 1/15th and 1/20th ) of the LD 50 extracts were injected intra-peritoneally for 14 consecutive days into three groups of animals (n ¼ 5 in each group), with one group used as a control and injected with distilled water through the same route. Blood was collected after sacrificing the animals and the following biochemical parameters were detected: glutamate pyruvate transaminase (GPT), glutamate oxaloacetate transaminase, alkaline phosphatase, cholesterol, glucose, triglycerides, creatinine and bilirubin. In addition, the total white blood (WBC) and red blood cells (RBC) were estimated in the blood of all groups. The gross and microscopic findings were reported after the collection of specimens from the animals, and processed routinely for standard histological procedures. The results showed an increase in the number of WBC, which indicated a defence response; while the RBC were decreased because of damage in tissues or organs. The gross and the microscopic changes seemed to be dosedependent, as very little or no effects were noticed in the lowest treated group, and more obvious changes were detected in the highest-dose group of animals. In addition, changes were observed in almost all biochemical parameters under investigation, with the exception of creatinine and GPT, which reflect the general effect of the material used on the animal health.

Identifying sociodemographic populations with a major depressive episode (MDE) who are at increased risk for binge alcohol use (BAU) is critical for developing focused prevention programs to meet the particular needs of each population. Thus, the goal of the current exploratory retrospective study is to examine sex, race, age, education, marital status, and income as risk predictors for BAU among adults with MDE; and if the risk for BAU changes after adjusting for demographic confounders. To achieve the study goal, data from the Substance Abuse and Mental Health Services Administration’s 2018 National Survey for Drug Use and Health were extracted and analyzed. The unweighted sample included 6,999 adults representing a weighted population size of 33,900,452.122 in the US. Results revealed that age and marital status significantly predicted BAU in the past month among adults with MDE. Adults under the age of 50, with a college degree, never married, divorced/separated, and with a high-middle income level or higher were at higher risk for BAU. The study's clinical implications are that understanding demographics of individuals with MDE at increased risk for BAU can inform improved tailored assessment and treatment of alcohol abuse and MDE among at-risk populations. Future research should consider examining additional potential risk factors for BAU among adults with MDE.