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Background: Injury or inflammation to the animal body resulted in the initiation of the acute-phase response (APR). Many plasma proteins increase in concentration in response to inflammatory stimuli, but C- reactive protein is considered as the most suitable markers due to their rapid and substantial increase in concentration and short half-lives. The CRP response varied according to the degree of surgical trauma on 3-standardized levels indicating CRP as an inflammatory activity indicator and monitoring markers. The aim of this study was to assess CRP concentrations in female dogs undergoing laparoscopic and open elective ovariectomy. Methods: The studies were conducted on twenty clinically healthy, adult, female dogs under elective spaying. Twenty healthy bitches were randomly assigned into four groups (A, B, C and D) consisting of five animals in each group. The studies were conducted in two phases (I and II).In phase I ovariectomy had been performed in animals of groups A and B with laparoscopy whereas, in phase II ovariectomy in animals of groups C and D were done by open laparotomy. Result: The pre-treatment CRP values did not show any significant change whereas post treatment values of group B were significantly lower as compared to groups D and C. On day 4th, group D values were significantly higher than groups C, B and A. Group C values were also significantly higher than group B. The highest value in group D might be due to more surgical manipulations and post-operative infection at surgical site in the animals under this group.

Aim: The aim of the present study was to retrospectively assess the healing of periapical lesions in permanent central incisors with open apices after unintentional extrusion of mineral trioxide aggregate (MTA). Materials and Methods: The clinical and radiographic records of 75 maxillary permanent central teeth treated by MTA apexification were evaluated. Teeth with unintentionally extruded MTA formed the study group (Group 1, n = 28), whereas the teeth with no MTA extrusion formed the control group (Group 2, n = 47). For both the groups, the records were analyzed for a follow-up period of 3 years. Results: Complete healing (CH) was observed in 25 teeth in the study group, whereas all the teeth in the control group showed CH ( P > 0.05). Within the study group, 6 teeth (21%) showed CH in the 6 th month in Group 1, whereas in the control group, 34 teeth (72.3%) showed CH ( P < 0.001). At the 1-year follow-up appointment, 19 teeth (67.8%) showed CH in Group 1, whereas 9 teeth (19.1%) showed the same result in Group 2 ( P < 0.001). At the end of the 3-year follow-up period, it was noticed that in 21 (84%) teeth, extruded MTA remained unchanged, whereas it was reduced in 4 (16%) of them ( P < 0.001). Conclusion: Extrusion of MTA does not have a significant effect on the healing of the periapical lesion. However, it may lead to a delay in the healing of periapical healing. Patients should be informed about the complication and consequences of extruded MTA and should be kept on follow-up to observe periapical healing.

Background: Many recent research shows that antidepressants interfere with the osseointegration of implants. The main purpose of this study was to determine the association between selective serotonin reuptake inhibitors (SSRI) and dental implant failure. Materials and Methodology: A retrospective study consisted of 410 patients (720 dental implants). Patients' records were used to retrieve the history of SSRI use and medication. The study consists of two groups. Group I (SSRI users) consisted of 128 patients (245 dental implants) patients, whereas Group II (non-SSRI users) was formed by 282 patients (475 dental implants). The implant failure rate was evaluated and statistically examined using the Chi-square test. Results: Group I had 30 implant failures with 13 (12%) males and 14 (11.8%) females, whereas Group II had 28 implant failures with 12 (6.3%) males and 16 (5.6%) females. In Group I, 26% of the implants failed in the age group >50 years, whereas it was 10.4% in Group II. However, in the age group <50 years, it was 6% and 4.2% Groups I and II, respectively. Group I shows that out of 40 implants in diabetic patients, 12 had failure, whereas in Group II, out of 32 implants placed in diabetics, 7 had failure. In smokers, 48% of the implants failed in Group I, and 29% in group II. In non-smokers the failure was seen in 7.7% cases in Group I and 2.1% cases in Group II. The difference was statistically significant ( P < 0.05). Conclusion: The usage of SSRIs is associated with an increased rate of implant failure. It has a deleterious effect on bone remodeling and leads to excessive osteoporosis.

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