Treatment with hyperbaric O2 (HBO) ameliorates ischemia-reperfusion (I/R) injury. Since tumor necrosis factor-alpha (TNF-alpha) plays an important role in I/R injury, we hypothesized that the effect of HBO in I/R injury may be due to its ability to inhibit TNF-alpha production. In this study, one group of rats received HBO during 60 min of ischemia (HBO group, n = 9), while control rats endured the same procedure but did not receive HBO (non-HBO, n = 9). A group of sham-operated control rats (SHAM, n = 6) underwent laparotomy without occlusion of the artery and HBO treatment. Intestinal I/R led to an increase in serum TNF-alpha concentration to [mean (SEM)] 165 (32) pg/ml (P < 0.01 vs SHAM rats). HBO attenuated this increase [34 (9) pg/ml; P<0.05 vs non-HBO group]. Intestinal I/R also resulted in a marked increase in lung myeloperoxidase content [0.62 (0.04) U/g vs 0.17 (0.02) U/g of SHAM rats, P<0.01]. HBO suppressed this increase [0.40 (0.04) U/g, P<0.05 vs non-HBO rats]. HBO ameliorated the injury to the intestine and lung. The number of neutrophils sequestered in the lung was reduced in HBO rats compared to non-HBO rats [6.4 (0.9) neutrophils/per oil field and 10.9 (2) neutrophils/per oil field, respectively; P < 0.05]. These findings demonstrate that HBO inhibits TNF-alpha production during intestinal I/R, and this reduced TNF-alpha production may be attributed to the beneficial effects of HBO.

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Interferon alpha-2b inhibits the growth and DNA synthesis of endometrioma cells in culture. This finding may have prospects for the treatment of endometriosis.

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biotica parenterale o che causano la morte del paziente, contribuiscono in modo pesante alla mortalità elevata che i pazienti con AR presentano rispetto alla popolazione generale. Per stratificare il rischio pro-infettivo dato da farmaci si deve considerare la frequenza aumentata di infezioni, che i pazienti affetti da AR hanno di base. Il rischio infettivo nei pazienti con artrite reumatoidePazienti affetti da AR hanno un aumentata mortalità in confronto alla popolazione generale: hanno un rischio maggiore di morire per malattie cardiovascolari, urogenitali, gastrointestinali, respiratorie, infezioni e tumori (1). Uno studio retrospettivo longitudinale di coorte nordamericano ha evidenziato un rischio maggiore dei pazienti con AR di contrarre infezioni severe e non severe. Il tempo di osservazione ha raggiunto in media i 12,5 anni. Un totale di 389 su 609 pazienti (64%) ha presentato almeno una infezione documentata da un medico e 290 (48%) sono stati ricoverati almeno una volta per infezioni severe. In totale sono state registrate 1.481 infezio-Parole chiave -Artrite reumatoide, infezioni, infliximab, etanercept, adalimumab.

The object was to study the concentration of nitric acid in chocolate cyst fluid. Chocolate cyst fluid was obtained by aspiration from endometriomas during laparoscopy and/or laparotomy in 12 patients with endometriomas. Chocolate cyst fluid was cleared of blood contamination and then used for the quantitative assay of nitric oxide. The concentration of nitric oxide in chocolate cyst fluid was observe to vary between 20.5 and 40.9 mM/l. It was concluded that the role of nitric oxide in the pathogenesis of endometrioma needs further evaluation. It may be a factor in increasing vascularity, bleeding, and some apoptotic changes in endometriotic tissue. (J GYNECOL SURG 17:115, 2001)