Effect of Interferon α-2b on Endometrioma Cells In Vitro

Badawy, Shawky Z.A.; Etman, Amr; Cuenca, Violeta; Montante, Anthony; Kaufman, Lee D.

doi:10.1097/00006250-200109000-00010

Cited by 3 publications

(5 citation statements)

References 11 publications

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“…A broad spectrum of immunological factors are involved in endometriosis [41]. Focusing on the important immune-modulating cytokine family of interferons (IFNs), human recombinant IFNa-2b has been shown to suppress the growth of cultured endometriosis cells in vitro in a dose-dependent manner [7], and clinical trials on intraperitoneal administration of IFNa-2b following surgical removal of endometriotic lesions have yielded ambiguous results regarding reoccurrence of symptoms [1,2].…”

Section: Introductionmentioning

confidence: 99%

Low prevalence of DNA viruses in the human endometrium and endometriosis

et al. 2010

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The chronic female disease endometriosis causes debilitating pain and lowered fertility. The aetiology is unknown, but indications of an infectious agent are present. This study investigates the possible involvement of a pathogenic virus in endometriosis patients and controls. DNA was purified from biopsies and subjected to highly sensitive PCR tests detecting human papillomavirus (HPV) types, the herpes family viruses HSV-1 and -2, CMV, and EBV, and the polyomaviruses SV40, JCV, BKV, KIV, WUV, and MCV. The prevalence of pathogenic DNA viruses in the human endometrium was generally low (0-10%). The virus prevalence was found to vary slightly when comparing the endometrium of healthy women and women with endometriosis. However, these were not significant differences, and no viruses were identified in endometriotic lesions. These results do not point towards any evidence that endometriosis is caused by these viruses.

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Section: Introductionmentioning

confidence: 99%

Low prevalence of DNA viruses in the human endometrium and endometriosis

et al. 2010

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“…In addition it is able to augment macrophage and NK cell cytotoxicity and stimulate development of cytotoxic T cells 31 . The growth of endometrioma stromal cells is inhibited by IFN‐ α 2b 8 . Ingelmo et al 7 used a murine model of experimentally induced endometriosis to evaluate the effect of IFN‐ α 2b on implant size.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, investigators have focussed on assessing the response of endometriosis to known immunomodulatory agents such as interferon (IFN)‐ α 2b, a type 1 interferon available in recombinant form, and have found reductions in endometriotic stromal cell growth in vitro and implant size in a murine model 7–9 …”

Section: Introductionmentioning

confidence: 99%

Anti‐Proliferative Effect of Mycobacteria, IFN‐γ and TNF‐α on Primary Cultures Derived from Endometrial Stroma: Possible Relevance to Endometriosis?

Clayton

Duffy

Wilkinson

et al. 2004

American J Rep Immunol

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“…Обнаруженное подавление ро-ста клеток является следствием ингибирования синтеза ДНК клетками. В исследовании выявлено заметное уменьшение поглощения культурой клеток, полученных из эндометриом 3H-тимидина в пробирке, при применении IFN-α2β в различных концентрациях [29].…”

Section: роль интерферонов в патогенезе генитального эндометриозаunclassified

“…Интерфероны представляют собой цитокины, участвующие в клеточном взаимодействии и иммунных реакциях и, исходя из представленного обзора литературы, наряду с другими цитокинами принимают непосредственное участие в патогенезе эндометриоза. В большинстве работ продемонстрирована эффективность применения IFN I типа при эндометриозе [27][28][29], однако описано и их отрицательное влияние в виде возникновения рецидивов и возобновления болевого синдрома при комбинированной терапии [57]. Имеются данные об участии IFN I типа в повышении восприимчивости эндометрия к имплан тации, но механизмы, при помощи которых они выполняют свои функции, до сих пор не изучены.…”

Section: заключениеunclassified

Interferons: pathogenetic rationale for the treatment of external genital endometriosis and clinical efficacy

et al. 2019

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Hypothesis/aims of study. Endometriosis is the main cause of infertility and social maladjustment in women, caused by the presence of inflammatory endometriotic implants outside the uterus. A number of chemokines, including interferons, compromise the immune response on the development of endometriosis raising the interest to the investigation of interferons in this context. Based on this, the purpose of this review was to study the role of interferons in the pathogenesis of external genital endometriosis and to assess the possibility of their application within comprehensive pathogenesis-based therapy. Study design, materials and methods: literature data of national and international investigations for the period from 1996 to 2018; systematic analysis and evaluation of the literary data. Conclusion. Type I interferons seem to be promising agents for understanding of the pathogenesis of endometriosis, and can be considered as targeted therapy for this disease. The mechanisms of their functions require a further study. Type II interferons may be used in the future as diagnostic markers for the assessment of the disease severity.

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Effect of Interferon α-2b on Endometrioma Cells In Vitro

Cited by 3 publications

References 11 publications

Low prevalence of DNA viruses in the human endometrium and endometriosis

Low prevalence of DNA viruses in the human endometrium and endometriosis

Anti‐Proliferative Effect of Mycobacteria, IFN‐γ and TNF‐α on Primary Cultures Derived from Endometrial Stroma: Possible Relevance to Endometriosis?

Interferons: pathogenetic rationale for the treatment of external genital endometriosis and clinical efficacy

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