Effects of TPN on Brain, Liver, and Food Intake in Rats

Meguid, Michael M.; Kubota, Akio; Yang, Zhong-Jin; Montante, Anthony; Gleason, John R.

doi:10.1006/jsre.1995.1056

Cited by 3 publications

(2 citation statements)

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“…In a study comparing rats on TPN vs. enterally fed rats, both given access to regular chow, at the end of a two-week experiment, brain glycogen and triglyceride levels were recorded. The authors noted that TPN rats had an 85% decrease in food intake, and a 23% increase in brain glycogen, indicating a connection between the amount of glycogen in the brain and drive for seeking enteral nutrition [ 43 ]. This was also reflected by an increase in glycogen phosphorylase and a concurrent decrease in glycogen synthase.…”

Section: Alterations Of Mechanical Signaling and Effects Of Tpn On Th...mentioning

confidence: 99%

Novel Therapeutic Approaches for Mitigating Complications in Short Bowel Syndrome

Bettag

Cunningham

et al. 2022

Nutrients

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Short bowel syndrome (SBS) is a particularly serious condition in which the small intestine does not absorb sufficient nutrients for biological needs, resulting in severe illness and potentially death if not treated. Given the important role of the gut in many signaling cascades throughout the body, SBS results in disruption of many pathways and imbalances in various hormones. Due to the inability to meet sufficient nutritional needs, an intravenous form of nutrition, total parental nutrition (TPN), is administered. However, TPN presents difficulties such as severe liver injury and altered signaling secondary to the continued lack of luminal contents. This manuscript aims to summarize relevant studies into the systemic effects of TPN on systems such as the gut–brain, gut-lung, and gut-liver axis, as well as present novel therapeutics currently under use or investigation as mitigation strategies for TPN induced injury.

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Section: Alterations Of Mechanical Signaling and Effects Of Tpn On Th...mentioning

confidence: 99%

Novel Therapeutic Approaches for Mitigating Complications in Short Bowel Syndrome

Bettag

Cunningham

et al. 2022

Nutrients

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“…22 Some investigators have examined the effect of TPN on the hypothalamus and appetite. [23][24][25] However, few reports provide the lived experience of being an HTPN patient solely from the patient's perspective. The actual numbers and locations of patients receiving HTPN in the United States are unknown.…”

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confidence: 99%

The Lived Experience of Home Total Parenteral Nutrition: An Online Qualitative Inquiry With Adults, Children, and Mothers

Silver

2004

Nut in Clin Prac

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Using qualitative methods allowed insight into the HTPN experience and depiction of the daily challenges of being total parenteral nutrition-dependent from patients' and caregivers' perspectives. It provides insight into their reactions and behaviors. By gaining this type of awareness and understanding, clinical protocols and services can be planned that are more likely to derive successful outcomes.

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