ABSTRAKPeran Th17 dalam patogenesis asma dan imunoterapi menjadi konsep dan paradigma terbaru. Imunoterapi merupakan salah satu manajemen di dalam asma dan memerlukan waktu yang lama sehingga sering mengakibatkan kegagalan terapi. Terapi adjuvant antara lain probiotik dan Nigella sativa diduga dapat meningkatkan efektifitas imunoterapi. Penelitian dilakukan untuk mengevaluasi efek pemberian imunoterapi, probiotik dan/atau Nigella sativa terhadap jumlah sel Th17, neutrofil dan skoring asma pada anak asma selama imunoterapi fase rumatan. Penelitian dilakukan pada 31 anak yang dikelompokkan secara acak yaitu imunoterapi plus plasebo atau imunoterapi plus Nigella sativa atau imunoterapi plus probiotik atau imunoterapi plus Nigella sativa plus probiotik selama 56 minggu. Pengukuran jumlah sel Th17 dan neutrofil dilakukan menggunakan flowcytometry setelah perlakuan. Asthma Control Test dilakukan untuk mengevaluasi gejala klinis. Data dianalisis menggunakan uji komparasi Anova One Way dan uji korelasi Pearson. Hasil menunjukkan tidak didapatkan perbedaan yang bermakna jumlah sel Th17 dan neutrophil antara kelompok perlakuan (p-value 0,199 dan 0,326). Asthma control test secara bermakna didapatkan perbedaan antara perlakuan imunoterapi plus probiotik dibandingkan imunoterapi saja. Skoring asma pada kelompok perlakuan imunoterapi plus probiotik adalah yang tertinggi (22,6). Jumlah sel Th17, neutrofil dan ACT menunjukkan hubungan yang lemah dan tidak bermakna secara statistik (r=-0,2) (p= 0,156). Jumlah sel Th17 dan neutrofil tidak didapatkan perbedaan yang bermakna. Skoring asma pada kelompok imunoterapi plus probiotik adalah yang tertinggi. Dapat disimpulkan tidak terdapat hubungan antara Th17, neutrofil dan skoring asma.Kata Kunci: Imunoterapi, neutrofil, Nigella sativa, probiotik, sel Th17, skoring asma (p-value 0,199 and 0,326 ABSTRACT The role of Th17 cells in the pathogenesis of asthma and immunotherapy is being the latest concept and paradigm. Immunotherapy in asthma management requires long periods of time and often causes failure of therapy. Administration of adjuvans such as probiotics or Nigella sativa has been considered to improve its efficacy. This study was conducted
Latar belakang. Kejang demam adalah bangkitan kejang yang terjadi pada anak berusia 6 bulan sampai 5 tahun tanpa disebabkan oleh proses intrakranial. Kejang demam merupakan kelainan neurologi tersering yang dijumpai pada anak.Tujuan. Untuk mengetahui hubungan kadar hemoglobin dengan kejang demam pada anak yang disebabkan ISPA.Metode. Penelitian analitik observasional dengan desain kasus kontrol. Data diambil dari rekam medik di RSUD Abdul Wahab Sjahranie Samarinda tahun 2016-2017 menggunakan teknik purposive sampling. Variabel bebas adalah kadar hemoglobin, sedangkan variabel tergantung adalah kejang demam yang disebabkan ISPA. Analisis statistik menggunakan uji t tidak berpasangan dan chi-square (x2), kemaknaan ditentukan berdasarkan nilai p<0,05. Hasil. Didapatkan sebanyak 62 pasien dengan rincian 31 kejang demam dan 31 demam tanpa kejang. Prevalensi kejang demam pada anak laki-laki 71%, sedangkan perempuan 29%. Angka kejadian terbanyak kejang demam adalah usia 0-12 bulan dan gizi baik. Berdasarkan analisis data menggunakan uji t tidak berpasangan didapatkan rata-rata kadar hemoglobin pada kejang demam adalah 11,04 g/dL dan demam tanpa kejang 11,6 g/dL (p=0,023). Pada uji chi-square (x2), menunjukkan terdapat hubungan yang bermakna antara kadar hemoglobin dengan kejang demam yang disebabkan ISPA (p=0,032, OR=3,906)Kesimpulan. Terdapat hubungan kadar hemoglobin dengan kejang demam pada anak yang disebabkan ISPA.
Dengue virus infection can manifest from mild to severe, which are undifferentiated fever, dengue hemorrhagic fever (DD), dengue hemorrhagic fever (DHF), and dengue shock syndrome (DSS), respectively. Mild and severe dengue infection is difficult to distinguish early in the course of the disease, and the clinical course is also difficult to "predict". Therefore, indicators were needed to predict the degree of dengue virus infection, thus appropriate treatment can be given. The study was aimed to determine the association of nutritional status, age, and sex with the degree of dengue infection in children. This study was an analytic observational study with a cross-sectional design. The samples were pediatric patients (0-18 years), who have been diagnosed with dengue virus infection and were hospitalized at the Abdul Wahab Sjahranie Hospital Samarinda in 2019. Purposive sampling technique was used to appointed 88 patients. The data obtained from the medical records. The bivariate association was statistically analyzed with chi-square test. The result showed a significant association between sex (p = 0.041) with the degree of dengue infection in children. Meanwhile nutritional status (p = 0.127) and age (p = 0.077) had no significant association with the degree of dengue infection in children. In conclusion, sex might serve as a predictor of the degree of dengue infection in children, in which male is more susceptible to worse manifestations.
The Relation between Age, Pre-transfusion Hemoglobin Level and Duration of Sickness on Quality of Life in Children with Thalassemia in Samarinda. Thalassemia is a genetic disease caused bya disturbance in the process of forming the hemoglobin chain of red blood cells that decreased the production or formation of hemoglobin. Children with Thalassemia will have transfusions for their whole life to maintain blood hemoglobin levels. The older age of the child will also increase the frequent of blood transfusions to support the child’s growth. Long and continuous transfusions also inadequate treatment will cause complications that affect the quality of life for people with Thalassemia. This study aims to analyze the relation between age, pre-transfusion hemoglobin level and duration of sickness on quality of life in children with Thalassemia in Samarinda. This research was an analytic observational study with a cross sectional design. The subjects were 32 children, aged 2-18 years, with major Thalassemia who werethe members of POPTI Samarinda. The data collected by medical records and the result from patient’s interview using PedsQl 4.0. Statistical analysis use Pearson Test. The resultshows there isno relation between age and quality of life in children with Thalassemia (p = 0.136), there is relation between pre-transfusion hemoglobin level with the quality of life in children with Thalassemia (p = 0.040) and there is relation between duration of sickness and quality of life in children with Thalassemia (p = 0.036). Based on the results of this study, it can be concluded that age has no relation to quality of life in children with Thalassemia. Pre-transfusion hemoglobin level and duration of sickness have relation to quality of life in children with Thalassemia. Keywords: Thalassemia, quality of life, age, pre-transfusion hemoglobin level, duration of sickness.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.