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Silica supported FeCl3 catalyzed simple protocol for the synthesis of bis-indolylmethanes was explored via grindstone chemistry. Synthesized compounds were screened virtually as inhibitor by targeting the binding site of SARS-CoV-2 main protease enzyme.

A simple, mild and efficient strategy for selective hydrolytic cleavage of the N-tert-butyloxycarbonyl (Boc) group is devised using a protic ionic liquid as an efficient catalyst. The deprotection reaction proceeded well for N-Boc protected aromatic, heteroaromatic, aliphatic compounds, and chiral amino acid esters and peptides. A wide range of labile protecting groups such as tert-butyl ester, tert-butyl ether, benzyloxycarbonyl (Cbz), TBDMS, O-Boc and S-Boc remained unaffected under the reaction conditions. Scheme 1 Chemoselective deprotection of N-Boc group in a peptide. Scheme 2 Probable mechanism of N-Boc deprotection reaction. 3204 | RSC Adv., 2015, 5, 3200-3205 This journal is

Polydiacetylenes have gained increasing attention as promising smart materials owing to their brilliant blue-to-red color transition in response to various microenvironmental perturbations. In this communication, we report a paper-based naked-eye colorimetric sensor array comprising 10, 12-tricosadiynoic acid (TCDA) and N-1-hexadecyl imidazole derivatives. Sensor arrays were prepared onto a filter paper using the suction technique, followed by UV irradiation. In this sensor system, the clay material hectorite was used as the host/support to enhance the mechanical stability of the paper-based sensor. Both the TCDA-clay and TCDA-clay-N-1-hexadecyl imidazole sensors were studied to sense 12 different volatile organic compounds (VOCs). Interestingly, the TCDA-clay sensor responded to 7 VOCs, whereas the TCDA-clay-N-1-hexadecyl imidazole sensor responded to all 12 VOCs. The presence of N-1-hexadecyl imidazole was advantageous with respect to response time, concentration, and the number of VOCs. Interestingly, the designed sensors also showed distinct response toward gasoline and the presence of kerosene in gasoline. Applications of the designed sensors toward the pollution level of car exhaust have also been demonstrated successfully.

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