Therapeutic potentials of plant iridoids in Alzheimer's and Parkinson's diseases: A review

Dinda, Biswanath; Dinda, Manikarna; Kulsi, Goutam; Chakraborty, Ankita; Dinda, Subhajit

doi:10.1016/j.ejmech.2019.03.009

Cited by 116 publications

(71 citation statements)

References 97 publications

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“…Fluoxetine ameliorated Cort-induced lipid peroxidation and GSH depletion, and this was in accordance with Jayakumar et al, and Rebai et al 54,55 . The antioxidant activity of oleuropein was previously reported in various tissues 56,57 and in the brain 58,59 . Oleuropein is a potent scavenger of peroxynitrite and superoxide anion radicals, as well as hydroxyl radicals, and its peroxyl radicals scavenging activity was twice that of Trolox 60,61 .…”

Section: Discussionmentioning

confidence: 81%

Oleuropein Reverses Repeated Corticosterone-Induced Depressive-Like Behavior in mice: Evidence of Modulating Effect on Biogenic Amines

Badr

Attia

Al-Rasheed

2020

Sci Rep

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Depression is still one of challenging, and widely encountered disorders with complex etiology. The role of healthy diet and olive oil in ameliorating depression has been claimed. This study was designed to explore the effects of oleuropein; the main constituent of olive oil; on depression-like behaviors that are induced by repeated administration of corticosterone (40 mg/kg, i.p.), once a day for 21 days, in mice. Oleuropein (8, 16, and 32 mg/kg, i.p.) or fluoxetine (20 mg/kg, positive control, i.p.1) was administered 30 minutes prior to corticosterone injection. Sucrose consumption test, open-field test (OFT), tail suspension test (TST), and forced swimming test (FST) were performed. Reduced Glutathione (GSH), lipid peroxidation, and biogenic amines; serotonin, dopamine, and nor-epinephrine; levels were also analyzed in brain homogenates. Corticosterone treatment induced depression-like behaviors, it increased immobility time in the TST, OFT, and FST, decreased the number of movements in OFT, and decreased sucrose consumption. Corticosterone effect was associated with depletion of reduced glutathione and increase of lipid peroxidation, in addition to modification of biogenic amines; decreased serotonin and dopamine. Oleuropein or fluoxetine administration counteracted corticosterone-induced changes. In conclusion, oleuropein showed a promising antidepressant activity, that is evident by improving corticosterone-induced depression-like behaviors, and normalizing levels of biogenic amines.

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Section: Discussionmentioning

confidence: 81%

Oleuropein Reverses Repeated Corticosterone-Induced Depressive-Like Behavior in mice: Evidence of Modulating Effect on Biogenic Amines

Badr

Attia

Al-Rasheed

2020

Sci Rep

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“…Although the clinical pathologies of these diseases have been described a long time ago, today there are drugs available only effective in reducing the symptoms of these diseases. The deposition of senile plaques and LBs in neuronal cells induces chronic stress, including oxidative stress and activation of microglial cells for the release of several pro-inflammatory cytokines, chemokines, and ROS, that are the major cause of these disorders [121].…”

Section: Oleuropein As Anti-amyloid Toolmentioning

confidence: 99%

Oleuropein, a Bioactive Compound from Olea europaea L., as a Potential Preventive and Therapeutic Agent in Non-Communicable Diseases

et al. 2019

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Growing scientific literature data suggest that the intake of natural bioactive compounds plays a critical role in preventing or reducing the occurrence of human chronic non-communicable diseases (NCDs). Oleuropein, the main phenolic component of Olea europaea L., has attracted scientific attention for its several health beneficial properties such as antioxidant, anti-inflammatory, cardio- and neuro-protective, and anti-cancer. This article is a narrative review focused on the current literature concerning the effect of oleuropein in NCDs, such as neuro- and cardiovascular diseases, diabetes mellitus, chronic kidney diseases, and cancer, by its putative antioxidant and anti-inflammatory activity, but also for its other peculiar actions such as an autophagy inducer and amyloid fibril growth inhibitor and, finally, for its anti-cancer effect. Despite the increasing number of published studies, looking at the beneficial effects of oleuropein, there is limited clinical evidence focused on the benefits of this polyphenol as a nutraceutical product in humans, and many problems are still to be resolved about its bioavailability, bioaccessibility, and dosage. Thus, future clinical randomized trials are needed to establish the relation between the beneficial effects and the mechanisms of action occurring in the human body in response to the intake of oleuropein.

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“…There is growing evidence that specific bioactive compounds present in plants used as spices, fruits, vegetables, and nuts can be effective against some cancers. Secoiridoids, isolated from Oleaceae family, which are now widely used in the fields of food and medicine, have been extensively investigated in recent years and have been shown to possess a variety of pharmacological effects [24][25][26][27][28][29], such as anti-diabetic [30,31], anti-oxidant [32,33], anti-inflammatory [34][35][36], immunosuppressive [37], neuroprotective [36,38,39], and anti-cancer [1,[40][41][42]. Multifloroside (4), together with 10-hydroxyoleoside 11-methyl ester (1), 10-hydroxyoleoside dimethyl ester (2), and 10-hydroxyligustroside (3), are all 10-oxyderivatives of oleoside secoiridoids.…”

Section: Discussionmentioning

confidence: 99%

Multifloroside Suppressing Proliferation and Colony Formation, Inducing S Cell Cycle Arrest, ROS Production, and Increasing MMP in Human Epidermoid Carcinoma Cell Lines A431

Zhang

Feng

et al. 2019

Molecules

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Multifloroside (4), together with 10-hydroxyoleoside 11-methyl ester (1), 10-hydroxyoleoside dimethyl ester (2), and 10-hydroxyligustroside (3), are all secoiridoids, which are naturally occurring compounds that possess a wide range of biological and pharmacological activities. However, the anti-cancer activity of 1-4 has not been evaluated yet. The objective of this work was to study the anti-cancer activities of 1-4 in the human epidermoid carcinoma cell lines A431 and the human non-small cell lung cancer (NSCLC) cell lines A549. The results indicate that 1-4 differ in potency in their ability to inhibit the proliferation of human A431 and A549 cells, and multifloroside (4) display the highest inhibitory activity against A431 cells. The structure-activity relationships suggest that the o-hydroxy-p-hydroxy-phenylethyl group may contribute to the anti-cancer activity against A431 cells. Multifloroside treatment can also inhibit cell colony formation, arrest the cell cycle in the S-phase, increase the levels of reactive-oxygen-species (ROS), and mitochondrial membrane potential (MMP), but it did not significantly induce cell apoptosis at low concentrations. The findings indicated that multifloroside (4) has the tendency to show selective anti-cancer effects in A431 cells, along with suppressing the colony formation, inducing S cell cycle arrest, ROS production, and increasing MMP.

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Therapeutic potentials of plant iridoids in Alzheimer's and Parkinson's diseases: A review

Cited by 116 publications

References 97 publications

Oleuropein Reverses Repeated Corticosterone-Induced Depressive-Like Behavior in mice: Evidence of Modulating Effect on Biogenic Amines

Oleuropein Reverses Repeated Corticosterone-Induced Depressive-Like Behavior in mice: Evidence of Modulating Effect on Biogenic Amines

Oleuropein, a Bioactive Compound from Olea europaea L., as a Potential Preventive and Therapeutic Agent in Non-Communicable Diseases

Multifloroside Suppressing Proliferation and Colony Formation, Inducing S Cell Cycle Arrest, ROS Production, and Increasing MMP in Human Epidermoid Carcinoma Cell Lines A431

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