The objective of this work is make tissue adhesives agent from Thai rice starch, then test the final products for scientific and medical properties following the laws of Thai health ministry, to demonstrate that this product can be used safely, as same as the standard product. The principal raw material is pharmaceutical grade, Thai rice starch powder. The additives are hydroxyapatite (HA) nanopowder, carboxymethylcellulose, lactic acid, gelatin, polyvinylalcohol and glycerol. All materials will be mixed in distilled water under high temperature, and dried into starch tissue adhesives plate hydrogel. The final product will be kept in medical package and sent for sterilization by gamma radiation. These products will be characterized by scanning electron microscopy (SEM), x-ray diffraction (XRD), stability in water, and adhesive bond strength test in wet environment.
Successful human tissue adhesives depend on sure parameters which cannot be matched by any one adhesive. In this work, the novel human tissue adhesive is fabricated from gelatin and coconut shell carbon nanopowder composite. Characteristics of the carbon powder and the product samples were then investigated by X-ray diffraction (XRD), scanning electron microscopy (SEM). Mechanical characterization and tissue adhesive bonding test of the final product were also performed.
The topical hemostatic agents in surgery are biomaterials that very important for surgeons to stop bleeding in the complicated areas. Currently available hemostatic agents are often expensive, ineffective or raise safety concerns. Synthetic rice starch-based sponge was an inexpensive and promising alternative. In this study, we synthesized and characterized a new hemostatic agent from rice starch and investigated their use as a hemostatic material. The rice starch-based sponge having interconnected pore were synthesized via blending of the rice starch and additive of carboxymethylcellulose (CMC), polyvinyl alcohol (PVA), and glycerol in hot water, freezing and drying by vacuum sublimation with enlarged porosity and rapid swelling behavior. Characteristics of the final products were then investigated by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) and scanning electron microscopy (SEM-EDS). In vivo studies using 4 rabbits with liver injury showed rice starch-based sponge blood aggregate formation as well as bulk blood coagulation inhibition. The biocompatibility tests showed that this sponge is safe and effective after follow-up for at least 6 months of animal and clinical trial.
The main objective of this work is to make an absorbable monofilament suture from Thai rice starch. The improvement of the mechanical properties of Thai rice starch polymer films were achieved by addition of small amount of gelatin, carboxymethylcellulose (CMC) and carbon nanopowders. The carbon nanopowders were produced from coconut shell in our laboratory room by milling method. The incorporation of carbon nanopowders with a high aspect ratio and/or an extremely large surface area into Thai rice starch polymer films improves their mechanical performances significantly. Additionally, the black color from carbon nanopowder is easily visualized in tissue during surgery. The manufacturing processes are very simple by blending of the raw materials in hot water and then dry heating in electric oven. The final product was characterized of microstructures and mechanical properties. The resulting Thai rice starch-carbon nanocomposites possess several advantages for manufacture of sutures: 1. high water resistance that can be uses in the human body. 2. high mechanical strength that appropriate to manufacture of sutures. 3. biocompatibility and bioabsorbable. 4. low cost. 5. Eco-friendly green nanocomposites. However, the method of size designation of sutures fibers and needle attachment are the problem which restricts our suture in really applications. The investigation of knowledge and simple technology of manufacture of suture and needle attachment will be performed.
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