Rice Starch–Based Sponge for Use as Topical Hemostatic Agent

Abstract

The topical hemostatic agents in surgery are biomaterials that very important for surgeons to stop bleeding in the complicated areas. Currently available hemostatic agents are often expensive, ineffective or raise safety concerns. Synthetic rice starch-based sponge was an inexpensive and promising alternative. In this study, we synthesized and characterized a new hemostatic agent from rice starch and investigated their use as a hemostatic material. The rice starch-based sponge having interconnected pore were synthesized via blending of the rice starch and additive of carboxymethylcellulose (CMC), polyvinyl alcohol (PVA), and glycerol in hot water, freezing and drying by vacuum sublimation with enlarged porosity and rapid swelling behavior. Characteristics of the final products were then investigated by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) and scanning electron microscopy (SEM-EDS). In vivo studies using 4 rabbits with liver injury showed rice starch-based sponge blood aggregate formation as well as bulk blood coagulation inhibition. The biocompatibility tests showed that this sponge is safe and effective after follow-up for at least 6 months of animal and clinical trial.

Effect of Dietary Energy Density on Increasing Blood Glucose Pattern and Hunger-Satiety Sensation

“…Increased of circulating glucose levels in the brain also increase functional connectivity between the hypothalamus, thalamus and striatum as well as decrease the cerebral blood flow thus full sensation will be achieved 15 . The result of this was the low energy density food produces a more stable blood glucose levels that lead to decreased of hunger sensation than in high energy density food 16 .…”

Effects of Algan hemostatic agent foam in rat femoral artery injury model: A randomized animal trial

“…Recently, the hemostatic effects of AHA foam have been reported [10][11][12]. In addition, the effectiveness and safety of the different forms of AHA have been studied [13][14][15][16].…”

Clinical Trial of a Novel Starch-Based Adhesive Bandages for Medical Dressing

“…Nowadays, plastic is a major environmental disaster, so eco-friendly substances should be an alternative. From previous invention [8][9][10][11][12][13][14][15], we have made a novel starchbased adhesive bandages for medical dressing. In brief, compositions of starch sponge were retro gradation starch, polyvinyl alcohol, distilled water, rice starch powder and povidone-iodine, all mixed under 70-90 o C by hot plate stirrer, then added glycerol, stirred into homogeneous solution, freeze-dried and cutting into desired size and shape (Fig.…”