Abstract:A new dihydrochalcone derivative, 4',6'-dihydroxy-2',4-dimethoxy-5'-(2''-hydroxybenzyl)dihydrochalcone (1) and one known dihydrochalcone, 4',6'-dihydroxy-2',4-dimethoxydihydrochalcone (2) were isolated from leaves and twigs of Cyathostemma argenteum. Their structures were established by spectral methods, mainly 2D NMR spectroscopic techniques, which involved combined applications of DEPT, COSY, HMQC and HMBC. The molecular structure of 1 was also confirmed by single crystal X-ray diffraction. The test compounds 1 and 2 displayed significant inhibitory activity at a dose of 1 mg/ear on edema formation at all determination times, with similar intensity as phenylbutazone.
The objective of this work is make tissue adhesives agent from Thai rice starch, then test the final products for scientific and medical properties following the laws of Thai health ministry, to demonstrate that this product can be used safely, as same as the standard product. The principal raw material is pharmaceutical grade, Thai rice starch powder. The additives are hydroxyapatite (HA) nanopowder, carboxymethylcellulose, lactic acid, gelatin, polyvinylalcohol and glycerol. All materials will be mixed in distilled water under high temperature, and dried into starch tissue adhesives plate hydrogel. The final product will be kept in medical package and sent for sterilization by gamma radiation. These products will be characterized by scanning electron microscopy (SEM), x-ray diffraction (XRD), stability in water, and adhesive bond strength test in wet environment.
The absorbable porous material, especially gelatin porous film, is widely used for surgical use to stop bleeding, but its price is quite high. Thus, a new material at lower price with desirable properties is required. This article presents an approach to prepare a porous film of silk fibroin-rice starch (SF-RS) modified with trisodium trimetaphosphate (STMP). The preparation was performed using freeze-drying method aiming to increase the porosity and improve some other properties of the modified porous film. The solutions of SF and RS (5 : 95 weight ratio) and STMP were mixed and adjusted to pH 12 before being neutralized to pH 7 and freeze-dried for 48 h. Result from the SEM images showed that the average pore size of the SF-RS film increased from 17 to 126 lm after STMP was added up to 5.0% w/w. Similar to the SF-RS-STMP hydrogel, the linkages within the modified SF-RS porous film also occurred mainly between the OAH groups of RS and the triphosphate group of STMP. Moreover, cross-linking density of the porous film increased with the increasing content of STMP, evidenced from the increase of relative methylene blue adsorption. The addition of STMP also affected the physical properties of the modified porous film such as degree of swelling, oxygen permeability, but not the water solubility. Whereas, the residual ash of the modified porous films was lower than 2.0% and the degradation of the film ceased after soaking in 0.01M PBS solution for about 2 weeks.
From ethyl acetate-methanol extracts of leaves and twigs of Pseuduvaria trimera a new aporphine alkaloid; 8-hydroxy-1,4,5-trimethoxy-7-oxoaporphine or 8-hydroxyartabonatine C (1) was isolated, together with the known 1,2,3-trimethoxy-4,5-dioxo-6a,7-dehydroaporphine (ouregidione, 2). Their structures were elucidated by a combination of spectral methods; mainly 2D NMR; IR and MS. Compounds 1 and 2 exhibited cytotoxic activity with IC 50 values of 26.36 ± 5.18 μM and 12.88 ± 2.49 μM, respectively, for human hepatocellular carcinoma HepG2 cells, and 64.75 ± 4.45 and 67.06 ± 3.5 μM, respectively, for human breast cancer MDA-MB231 cells. Both compounds displayed anti-cancer activity but less than that of doxorubicin; a conventional chemotherapeutic drug, the IC 50 levels of which were 2.21 ± 1.72 and 1.83 ± 0.09 μM for HepG2 and MDA-MB231 cells, respectively.
Successful human tissue adhesives depend on sure parameters which cannot be matched by any one adhesive. In this work, the novel human tissue adhesive is fabricated from gelatin and coconut shell carbon nanopowder composite. Characteristics of the carbon powder and the product samples were then investigated by X-ray diffraction (XRD), scanning electron microscopy (SEM). Mechanical characterization and tissue adhesive bonding test of the final product were also performed.
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