Artesunate is a much better drug than quinine in complicated malaria in terms of rapid coma resolution, fever clearance, parasite clearance and better tolerability.

Introduction: Incidence of Hypoxic Ischemic Encephalopathy (HIE) is 2-4 per 1000 live birth in USA, 1.8 per 1000 live births in Sweden, 3.8 per 1000 term live births in Australia. In India the incidence of HIE is 10-15 per 1000 live birth. The survivors from severe HIE develop cerebral palsy and mental handicaps as high as 50%. Concurrent use of cranial ultra sound and clinical staging systems are evolving to predict the prognosis. Objective: To study the cranial ultrasonogrphic finding in HIE Infants and its clinical correlation and prediction of outcome. Method: it is a prospective clinical study of 120 baby suffering from hypoxic ischemic encephalopathy. Result: Co-relation of initial cranial ultra sonography grading with mortality and sequel showed an increasing trend as the ultrasonography grading increases, with 51.4% mortality in grade –III, 18.5% in grade-II and 15.4% in grade –I. Seqele 48.6% was observed only in grade-III sonographic abnormality. Conclusion: Sonographic grading is more accurate than the clinical staging in predicting recovery, mortality and sequel.

Background: Urinary tract infection (UTI) is a common bacterial infection in children. Even a single confirmed UTI is serious, due to the potential for recurrent UTI, parenchymal damage, hypertension and renal failure.

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The classical Bartter syndrome is an uncommon tubular disorder of autosomal recessive inheritance, characterized by early childhood onset of polyuria, polydipsia, vomiting, dehydration, constipation and salt craving habit. The long-term outlook for patients with Bartter syndrome is not certain. If not properly treated, it may lead to failure to thrive and growth retardation. We herein report a case of 18-month-old girl child who presented chronic diarrhea and failure to thrive and then was diagnosed as a case of classical Bartter syndrome. She was successfully treated with potassium supplementation and ibuprofen therapy.

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