Using data from the National Health Interview Survey for years spanning 1976 to 2001, this paper presents an age-period-cohort analysis of weight gain throughout the life cycle. We find that while all ages experienced an increase in the proportion overweight and/or obese (PO&O), the PO&O of young adults has grown at a faster rate than that of older age groups. We find that the increases in Body Mass Index are primarily due to period effects, not cohort or age effects. From the ordered logistical regression analyses, we find that protective influence of factors such as education, income, and age on an individual's Body Mass Index have decreased over time. The analyses suggest that the increase in PO&O is a phenomenon that all demographic groups in the United States have experienced.
Objective:
The goal was to develop an updated model to predict the risk of recurrence, based on the number of adverse pathologic features in women with International Federation of Gynecology and Obstetrics stage I uterine endometrioid carcinoma, who did not undergo any adjuvant treatment.
Material and Methods:
Women at a single center who underwent surgical staging without adjuvant therapy between January 1990 and December 2019 were included. Cox proportional hazards model was used to identify independent predictors of relapse free survival (RFS). Prognostic groups were then created based on the number of independent predictors of recurrence that were identified (0, 1, or 2-3 risk factors). Overall survival (OS) and disease specific survival (DSS) were also calculated for each group.
Results:
In total 1133 women were eligible for inclusion. Median follow-up was 84 months. Independent prognostic factors of recurrence included: age ≥60; grade 2 or 3 differentiation; and presence of lymphovascular space invasion (LVSI). Due to the small number of patients with either 2 or 3 risk factors, these groups were combined into one (group 2/3). Isolated vaginal cuff recurrence was the most common site of recurrence in all study groups (2%, 7%, and 17% for groups 0, 1, and 2/3, respectively). Five-year RFS rates were 96%, 85%, and 57% for groups 0, 1, and 2/3 (p<0.01), respectively. Five-year DSS rates were 99%, 96%, and 85% and 5-year OS rates were 94%, 85%, and 62% (p<0.01), respectively.
Conclusion:
We identified older age, high grade, and presence of LVSI as independent predictors of recurrence for women with stage I uterine endometrioid carcinoma. Using these prognostic factors, recurrence risk can be quantified for individual patients, and these factors can be used in deciding the appropriate adjuvant management course.
An analysis of clinical toxicity and quality of life as a function of radiation dose and volume after lung stereotactic body radiation therapy (SBRT), Advances in Radiation Oncology (2021), doi:
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