Povidone iodine is an antiseptic that is often used for wounds after tooth extraction, but is often debated because it can cause damage to cells and tissues. African leaf (Vernonia amygdalina Del.) from the family Asteraceae has saponins as anti-microbial, anti-inflammatory and antioxidant flavonoids as that all may be able to accelerate wound healing. To investigate the activity of extracts of Vernonia amygdalina folia (VAF) to accelerate the process of wound healing after tooth extraction in rats. VAF extracted by maceration using methanol. Wistar male rats as much as 6 groups (n = 5 mice each group) performed tooth extractions, and then observed the reduction of gingival socket closure for 21 days after being given povidone iodine, distilled water and methanol extract group VAF by 4 concentration. The closure of the wound after tooth extraction in the group of povidone iodine rats occurred on the 8th day, the group aquadest cover the wound occurred on the 12th day, the extract group 1, 3, 5, 7% sequentially occur wound closure on day 6th, 5th, 4th and 4th. VAF methanol extract of the leaves can accelerate wound healing after tooth extraction of mice.
Background: The Covid-19 is a viral infection caused by the novel coronavirus and interpersonal transmission occurs mainly via respiratory droplets and contact transmission. In some countries, the recommendations of the dental associations are to interrupt elective dental treatments, so only emergency or urgent cases are allowed. However, many patients are not aware of whether or not to attend their appointments at the dental clinic. Most of the patients are anxious but some patients feel calm to seek dental treatment. Purpose: This research is to find out the impact of the Covid-19 pandemic on anxiety levels and patient’s visit in Dental and Oral Clinic, A.W. Sjahranie General Hospital Samarinda. Materials and Method: This research was designed by the descriptive observational approach using a cross-sectional research design. The samples were new patients of child and adult who visited Dental and Oral Clinic, A.W. Sjahranie General Hospital Samarinda. The research was conducted through questionnaires to measure anxiety levels about Covid-19 pandemic conditions and the average anxiety level of patients associated with "stay at home" recommendation and their impact on dental care success. Result: The questionnaires were answered by 55 patients (23 male/42% and 32 female/58%) who visited the Dental and Oral Clinic, A.W. Sjahranie General Hospital Samarinda. The average level of patient anxiety for Covid-19 pandemic conditions is 4.87 for male patients and 4.42 for female patients. The level of anxiety about the impact of the Covid-19 pandemic on dental care is about the same in both men and women. Conclusion: Male patients are more anxious than women about the Covid-19 pandemic. But both showed similar anxiety about how pandemic conditions could affect their dental care.
Inflammation is a normal process in the human body as a response to injury Keywords: Anti-inflammatory, in vitro, Vernonia amygdalina, membrane stabilization ABSTRAKPeradangan adalah proses normal sebagai respon terhadap jejas, yang berperan penting dalam proses penyembuhan. Namun proses peradangan yang kronis akan menimbulkan masalah bagi pasien. Untuk mengatasinya digunakan agen anti-inflamasi yang memiliki efek samping terkait penggunaannya. Hal ini membuat pentingnya pencarian alternatif obat anti-inflamasi, terutama yang berasal dari bahan alam. Vernonia amygdalina Delile dikenal masyarakat lokal dengan nama "Daun Bismillah" merupakan salah satu sumber bahan alam yang potensial sebagai agen anti-inflamasi. Tumbuhan ini digunakan sebagai obat tradisional dan digunakan sebagai material dalam penelitian ini. Metode pengukuran anti-inflamasi in vitro yang digunakan adalah pengukuran aktivitas stabilisasi membran dari ekstrak etanol daun V. amygdalina. Hasilnya menunjukkan perbedaan signifikan EC50 (p<0,05) antara indometasin sebagai kontrol positif, dengan ekstrak etanol daun V. amygdalina konsentrasi 1% dan 10%. Hasil EC50 V. amygdalina menunjukkan aktivitas anti-inflamasi yang potensial. Dapat disimpulkan bahwa ekstrak etanol daun V. amygdalina memiliki aktivitas anti-inflamasi, yang dapat dikembangkan lebih lanjut sebagai sumber bahan alam baru untuk agen anti-inflamasi.Kata kunci: Anti-inflamasi, in vitro, Vernonia amygdalina, pengujian stabilisasi membran. Submitted on: 7 November2017Accepted on: 1 Desember 2017 DOI: https://org.doi/10.25026/jsk.v1i8.80 PENDAHULUANInflamasi merupakan sebuah proses fisiologis dalam tubuh sebagai respon terhadap adanya jejas pada bagian tubuh, seperti pada kondisi kelelahan akibat kerja. Inflamasi akut dapat dipicu oleh berbagai rangsangan dan ditandai dengan respon cepat host pada lokasi infeksi atau
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