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This study introduces two new processes that highly enable PEDOT:PSS (poly(3,4-ethylenedioxythiophene)-poly(styrenesulfonate)) as stable coating material for chronic neural stimulation. In first process, strong mechanical bonding between PEDOT:PSS coating and gold electrodes is achieved by creating rough porous surface with partial iodine etching. PEDOT:PSS coating on iodine etched gold electrode shows 100% stability under strong ultrasonic treatment. The second process represents electrochemical modification of PEDOT:PSS coating by cyclic voltammetry method in Ringer's solution. This process reduces electrode polarization 33% during stimulation. Therefore, charge injection capacity increases that ensures safe stimulation. A combination of both processes facilitates the use of PEDOT:PSS coating for successful chronic neural recording and stimulation.

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Parylene-C, a biocompatible coating material, does not adhere well to metals. This is problematic especially for biomedical devices containing gold structures. In this contribution, we present a simple method to adhere Parylene-C to gold-coated substrates based on thiol-based adhesion promoters. The effectiveness of the adhesion promoters has been demonstrated by pulltests on autoclaved Parylene-C coated gold-substrates.

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