How to cite this paper: Martínez-Soriano, P.A., et al. (2015)
AbstractA convenient and easy method is described for the formation of carboxamides from carboxylic acids and primary amines in solventless conditions using infrared (IR) light. Thus, under IR light, cinnamic acid derivatives and amines can produce yields ranging from 50% to 85% of the resulting amide.
24-bromo-2-thiomorpholin-4-ylmethyl-1-phenol (2) was prepared from 4-bromophenol (1) and thiomorpholine and formaldehyde (2 eq.) and 1 eq. of thiomorpholine. They were mixed in a round flask fitted with a condenser. The mixture was irradiated with infrared light using a medicinal infrared lamp (250 Watts) and the reaction was monitored by tlc, and after 7 minutes, the reaction was completed. The mixture was chromatographed on silica gel using solvent gradient hexane/ethyl acetate. Yield 63%
AcknowledgementsThe authors wish to acknowledge to PAPIIT/UNAM Projects No IN213606 and IN207705 and M548 -Synthesis of 4-bromo-2-thiomorpholin-4-ylmethyl-1-phenol
The balance between cell proliferation and cell growth characterizes tissue homeostasis on one side and cell death on the other side. Fas receptor-mediated apoptosis is a control mechanism for tissue homeostasis, and avoiding this death pathway predisposes to many human diseases, including cancer. Current therapies for this disease are invasive and do not have the desired effect in the control of the disease. In this context, the search for new drugs that contribute to a better treatment is gaining more relevance. 4-tert-butyl-bis-(2,6-thiomorpholin-4-ylmethyl)-1-phenol (LQM319) [1,2] is a drug currently in preclinical stage, and we have shown that it has a hypertensive effect, similar to captopril, in a hypertensive rat model. Different studies have shown that some chemicals that are used as antihypertensive agents have an antineoplastic effect against certain types of cancer, as is the case of hydralazine [3], and captopril [4], among others [5]. On the other hand, it has been reported that morpholine derivatives may activate Fas (CD95)-mediated apoptosis. The aim of the present study was to show the interaction between CD95 (receptor) and thiomorpholine derivatives (ligand) using molecular modeling and docking studies, and to elucidate the possible action mechanism of 4-tert-butyl-bis-(2,6-thiomorpholin-4-ylmethyl)-1-phenol.
<p>Cuando los sitios y herramientas web están bien diseñados<br />y codificados, las personas con discapacidad pueden<br />utilizarlos. Según la Organización Mundial de la Salud<br />(Organización Mundial de la Salud [OMS], 2021) hay más<br />de mil millones de personas viven en todo el mundo que<br />viven con alguna forma de discapacidad. Sin embargo, en<br />la actualidad muchos sitios y herramientas están<br />desarrollados de tal manera que presentan diversas<br />barreras de accesibilidad que dificultan o imposibilitan su<br />uso por parte de algunas personas. El propósito de este artículo es describir los aspectos<br />considerados para el diseño accesible, de la nueva<br />generación de asignaturas B21 de Bachillerato a Distancia<br />UNAM, con base en los parámetros de accesibilidad de la<br />W3C (2019). Como ejemplo, se describe el proceso<br />creativo detrás de dos asignaturas: Evolución y<br />biodiversidad y Apreciación estética .</p>
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