This review discusses basic aspects used to control the architecture and functional properties of smart hydrogels. The introduction briefly outlines what has been accomplished regarding smart hydrogels and explores historical aspects and the fundamental understanding of these systems. Then, a short discussion on the chemical interactions and the main variables involved in architectural construction is exhibited. Further analysis provides the basis for optimizing biological responses through system modulation. Finally, we outline perspectives and challenges for building smart hydrogels into functionalized and modulated delivery systems.

Surface engineering of silica nanoparticles for oral insulin delivery: characterization and cell toxicity studies, Colloids and Surfaces B: Biointerfaces (2014), http://dx.doi.org/10. 1016/j.colsurfb.2014.10.047 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. high biocompatible, at the tested concentrations (50 -500 μg/mL), revealing no or low 51 toxicity in the two human cancer cell lines (HepG2 and Caco-2). In conclusion, the 52 developed insulin-loaded SiNP surfaced with mucoadhesive polymers demonstrated its 53 added value for oral administration of proteins. 54 55 56

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