No abstract

No abstract

No abstract

The present study compared morphological, histochemical and histomorphometric characteristics of the sublethal effects of XenTari® and deltamethrin in blastocyst-endometrium interactions in female rats. Pregnant rats received 185, 1850 and 3700mg of XenTari® or 1.0, 2.0 and 4.0mg of deltamethrin (all doses per kg of body weight) and were sacrificed on the seventh day of pregnancy. The rats treated with the higher doses of insecticides exhibited a significant reduction in the number of implantation sites, vacuolated trophoblast cells, rare cytotrophoblasts, accentuated leukocyte infiltration, increase in vascularization of sites and blood in the uterine lumen. The decidua was more fibrous, particularly in the rats treated with the highest dose of XenTari®. In conclusion, sublethal doses of both XenTari® and deltamethrin produced qualitative/quantitative alterations in the blastocyst-endometrium interaction in female rats, thereby compromising the implantation process. Further studies are needed particularly at verifying the effects of these insecticides in the pregnancy to term in rats, order to investigate possible correlated effects on women working or living near agricultural fields.