Nesidioblastosis is characterized by hyperfunction of pancreatic islets caused by hypertrophic beta cells. Postprandial symptoms of hypoglycemia are the clinical presentation of the disease. A female patient with diabetes mellitus who underwent a Roux-en-Y gastric bypass began to present postprandial symptoms of hypoglycemia. There was no radiologic (MRI) evidence of insulinoma. Selective arterial calcium-stimulation test identified hyperfunction only in the splenic artery. Laparoscopic spleen-preserving distal pancreatectomy was performed. The patient has been entirely free of any postprandial symptoms for 10 months after the partial pancreatectomy.

This study demonstrates that the existence of OSA prior to bariatric surgery interferes in the improvement of endothelial function.

Overweightness is related to a high incidence of dyslipidemia, being considered a risk factor for cardiovascular diseases.Objective: Analysis of the effect of weight loss in reducing type 2 diabetes mellitus and cardiovascular risk 2 years after Roux-en-Y gastric bypass.Methods: A retrospective study with patients who underwent Roux-en-Y gastric bypass involving accessing the database of an Obesity Surgery Clinic from March 2018 to March 2019. Male and female patients, aged 18 and over, who underwent bariatric surgery from March 2014 to March 2016 were analyzed. The following data were obtained from the medical records of patients: body weight, height, age, sex, glucose and glycated hemoglobin (HbA1C) after 24 months of surgery.Results: In total, 351 patients were studied, 80.9% of whom were female. There was a reduction in weight and in the concentrations of all biochemical parameters, except HDLc, along with a decrease in the frequency of dyslipidemia and cardiovascular risk 24 months after surgery. When comparing variations between 6 and 12 months, only group 1 reduced Hb1Ac and decreased CVR. There was a significant reduction in the level of glucose in group 1 (p = 0.036) at T4 (18 months) and T5 (24 months).Conclusion: The positive impact determined by bariatric surgery on weight loss was shown to be effective in improving the dyslipidemic profile, reducing morbidities associated with obesity and, consequently, reducing CVR after 24 months.

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Objectives: Dyspnea (shortness of breath) is common among obese individuals. However, no studies have evaluated the effect of dyspnea on oral health-related quality of life (OHRQoL). The aim of the present study was to evaluate the impact of dyspnea on the OHRQoL of obese individuals prior to bariatric surgery. Methods: A cross-sectional study was conducted with 104 obese individuals. Data were collected on socio-demographic characteristics, body mass index, perceptions of xerostomia (dry mouth), tooth loss and OHRQoL (OHIP-14). Poisson regression analysis was used to determine the association between dyspnea and OHRQoL. Results: Individuals with dyspnea had higher total OHIP-14 scores (1.40 ± 3.74) compared to those without dyspnea (0.50 ± 0.39) (P = 0.005). In the multivariate analysis, total OHIP-14 scores were 3.91-fold higher among the individuals with dyspnea. All domains of the questionnaire were associated with dyspnea, except physical disability and psychological disability. Conclusion: Dyspnea exerted a negative impact on OHRQoL in obese individuals, independently of socio-demographic and clinical characteristics.