Unexpected early tumor recurrence in patients with hepatitis C virus-related hepatocellular carcinoma undergoing interferon-free therapy: Issue of the interval between HCC treatment and antiviral therapy

As the COVID-19 pandemic spreads around the world, professionals must prepare for an increase in severely ill patients. Considering that professionals who perform oral care, especially the oral health team, is the most exposed to SARS-CoV-2, and that saliva can be the main vector in the transmission from person to person, it is essential that they are supported by the best evidence for their performance with risk reduction. In view of the literature, the clinical studies of COVID-19 do not often describe oral symptoms, and it is still uncertain whether these manifestations may be a typical clinical pattern resulting from direct SARS-CoV-2 infection or a systemic consequence, given the possibility of co-infections, impaired immune system and adverse drug reactions. As the prevalence of clinical manifestations is still unknown, the possible manifestations of COVID-19 in the oral cavity has been considered of wide and current interest. Therefore de aim of this study was to report a case series of oral lesions in patients infected with SARS-CoV-2.

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Efeito Antimicrobiano do Extrato da Matricaria recutita Linn. (Camomila) sobre Microrganismos do Biofilme Dental

Albuquerque¹

2010

Pesq Bras Odontoped Clin Integr

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Loss of heterozygosity in P53, BRCA1, and estrogen receptor genes and correlation to expression of p53 protein in ovarian epithelial tumors of different cell types and biological behavior

et al. 2000

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Estudo da prevalência de Leishmaniose Tegumentar Americana com repercussão na cavidade bucal no município de Alagoa Grande (PB)

Albuquerque¹,

Pereira

Oliveira

et al. 2010

cmbio

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<span style="font-size: 11pt; font-family: ">O objetivo desta pesquisa foi<span style="color: red;"> </span>estudar a prevalência da leishmaniose tegumentar americana com repercussão na cavidade bucal, no município de Alagoa Grande (Paraíba), no período compreendido entre 1996 e 2004. Foi utilizada, para a pesquisa, a verificação das fichas clínicas da Leishmaniose Tegumentar, na Secretaria da Saúde da referida cidade, onde se observou a existência ou não de repercussão nasobucofaríngea. 53 pacientes apresentaram Leishmaniose Tegumentar Americana, 64% eram do sexo masculino, na faixa etária entre 20 e 24 anos e mais de 65 anos; 45,16% eram analfabetos, 96,2% apresentaram lesões cutâneas, 3,8% lesões na mucosa, 3,8% apresentaram repercussões bucais, 100% realizaram a Intradermorreação de Montenegro para confirmar o diagnóstico clínico, e 61,29% faziam uso de antimonial penta valente. O índice de prevalência mucoso foi de 0,67 casos para cada 10.000 habitantes. Concluiu-se que estudos de prevalência demonstram a real situação da epidemiologia no país, havendo a necessidade de os cirurgiões-dentistas observarem as características regionais de cada afecção como forma de melhor diagnosticá-las. A Leishmaniose Tegumentar no município de Alagoa Grande, Paraíba, demonstra bem essa necessidade, devido às suas características epidemiológicas.</span>

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The anti-adherence effect of Lippia sidoides Cham: extract against microorganisms of dental biofilm

Albuquerque

Pereira

Silva³

et al. 2013

Rev. bras. plantas med.

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RESUMO: Efeito anti-aderente de Lippia sidoides. Extrato contra microorganismos do biofilme dental. É fato comprovado que a maior parte das doenças que acometem a cavidade bucal são de origem infecciosa. Várias categorias de agentes químicos têm sido utilizadas no controle químico do biofilme dental através de estratégias que visam a redução da adesão bacteriana, a inibição do crescimento, e a proliferação dos microrganismos na superfície do dente. A utilização das plantas pela medicina popular, seu uso na Odontologia e a divulgação dos êxitos, conduziram a exploração científica resultando no conhecimento químico-farmacológico de milhares de plantas. A presente pesquisa objetivou avaliar a atividade antiaderente da folha da Lippia sidoides Cham. comparando seus resultados com a Clorexidina 0,12%, através de uma simulação, in vitro, do biofilme dental. As linhagens bacterianas utilizadas na pesquisa foram o Streptococcus mutans, Streptococcus sanguinis, e o Lactobacillus casaram, principais responsáveis pela aderência do biofilme. O extrato estudado mostrou-se efetivo na inibição de aderência das bactérias ensaiadas até uma concentração de 1:16, sobre o Streptococcus mutans, sendo comparável à Clorexidina. O extrato da Lippia sidoides Cham. demonstrou efeito antiederente, sobre os principais microrganismos responsáveis pela consolidação do biofilme dental. Palavras-chave:Biofilme dental, Microrganismos, Lippia sidoides. ABSTRACT:Most illnesses affecting the oral cavity are proven to have infectious origin. Several categories of chemical agents have been used in the chemical control of dental biofilm through strategies that aim at reducing bacterial adhesion and inhibiting the growth and the proliferation of microorganisms on the tooth surface. The use of plants in folk medicine and in Dentistry, as well as the spread of successful cases, has led to scientific exploration, resulting in chemicalpharmacological knowledge of thousands of plants. The present study aimed to evaluate the anti-adherence activity of Lippia sidoides Cham., comparing the results with those of 0.12% chlorhexidine by means of an in vitro simulation of dental biofilm. The studied bacterial strains were Streptococcus mutans, Streptococcus sanguinis and Lactobacillus casei, main responsible for the biofilm adherence. The studied extract was effective in inhibiting the adherence of Streptococcus mutans up to a concentration of 1:16, compared to Chlorhexidine. Lippia sidoides Cham extract showed anti-adherence effect on the major microorganisms responsible for dental biofilm consolidation.

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Loss of Heterozygosity of p53, BRCA1, VHL, and Estrogen Receptor Genes in Breast Carcinoma: Correlation with Related Protein Products and Morphologic Features

Otis¹,

Krebs

Albuquerque³

et al. 2002

Int J Surg Pathol

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Correlation of loss of heterozygosity (LOH) of p53, BRCA1, VHL, and estrogen receptor (ER) genes with the expression of related protein products and morphologic features predictive of aggressive biologic behavior was investigated to determine the significance of LOH in these genes. DNA from 35 formalin-fixed, paraffin-embedded breast carcinomas was obtained by microdissection of histologic sections. LOH was determined by polymerase chain reaction (PCR) using primers TP53, D3S1038, D17S855, and ESR for p53, VHL, BRCA1, and ER genes, respectively. p53, ER, and progesterone receptor (PR) protein expression was evaluated by immunohistochemistry. Morphologic evaluation included histologic type, and histologic and nuclear grades. TP53 LOH was identified in 13 (52%), BRCA1 LOH in 3 (17%), VHL LOH in 1 (4%), and ER LOH in 4 (21%) of 25, 17, 24, and 19 informative cases, respectively. p53 and ER protein expression was identified in 20 (57%) and 25 (71%) cases, respectively. TP53 LOH directly correlated with both high histologic and nuclear grade (P<0.01). BRCA1, VHL, and ER LOH was not frequent enough for correlation to morphologic features. Although 4 of 4 ER and 7 of 13 p53 LOH cases expressed related proteins, LOH did not correlate with protein expression. TP53 LOH may be an event contributing to aggressive biologic behavior since it is strongly associated with high histologic and nuclear grade. Missense or nonsense mutations may explain the absence of detectable p53 protein in 6 of 13 cases with p53 LOH. All 4 ER LOH cases expressed ER protein. BRCA1 and VHL LOH is infrequent in sporadic breast carcinoma.

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Digital image filters are not necessarily related to improvement in diagnostic of degenerative bone changes in the temporomandibular joint on cone beam computed tomography

Marques

Costa

Baeder

et al. 2021

RSD

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This study assessed whether the use of digital image filters influences the detection of temporomandibular joint (TMJ) bone changes on cone beam computed tomography (CBCT). Two radiologists evaluated the TMJ images of CBCT scans to verify the presence of osteophytes, erosions, pseudocysts, bone sclerosis and flattening, using the software XoranCAT®; each image of the TMJ was assessed with and without the use of the following filters: Angio Sharpen 3x3 and Angio Sharpen 5x5. Kruskal-Wallis’ test was used to assess whether the application of filters influenced the scores assigned to the degenerative bone changes in the condyle. Flattening was present in 15 cases (51.72%), followed by osteophytes in six cases (20.69%), sclerosis in three cases (10.34%), and erosion in three cases (10.34%), with pseudocyst found in two cases (6.90%). No statistically significant difference was found in the scores (P = 0.786) regarding the original images and those treated with both filters. Digital image filters used in our study did not influence the diagnosis of degenerative bone changes in the TMJ on CBCT images.

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Accuracy assessment of different CBCT acquisition protocols used in rapid prototyping models

Corazza

Baeder

Silva

et al. 2020

RSD

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This study compared the acquisition protocols of the Conical Beam Computed Tomography (CBCT) system, to assess the influence on image accuracy by different voxel sizes and the presence of soft tissue. Tomographic acquisition was performed in a fresh (F) and dry (D) pork jaw with voxel sizes of 0.4, 0.3 and 0.25 mm. The gold standard was obtained by scanning dry jaws covered with barium sulfate with a voxel size of 0.25 mm. The images were treated in the MIMICS® program, and noise areas were removed manually, using a fixed threshold for the purpose of generating 3D printing windows. Each window was virtually overlaid with the gold standard using the MeshLab software, obtaining absolute error values between the meshes, generating a map of discrepancies. Significant differences were found between windows D 0.30 vs. F 0.30, D 0.30 vs. F 0.25, D 0.30 vs. D 0.25, D 0.30 vs. F 0.40, F 0.30 vs. D 0.25, F 0.25 vs. D 0.25, F 0.25 vs. D 0.40, D 0.25 vs. F 0.40, D 0.25 vs. D 0.40 and F 0.40 vs. D 0.40, (p <0.05). It was observed that the dry jaw windows showed a lower mean and standard deviation when compared to the fresh jaw windows. The 0.25 mm voxel protocol showed the most accurate result and the presence of soft tissues influenced the accuracy of the image when some protocols were compared statistically.

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Ana Carolina Lyra de Albuquerque

Oral lesions in patients infected with SARS-CoV-2: a case series

Efeito Antimicrobiano do Extrato da Matricaria recutita Linn. (Camomila) sobre Microrganismos do Biofilme Dental

Loss of heterozygosity in P53, BRCA1, and estrogen receptor genes and correlation to expression of p53 protein in ovarian epithelial tumors of different cell types and biological behavior

Estudo da prevalência de Leishmaniose Tegumentar Americana com repercussão na cavidade bucal no município de Alagoa Grande (PB)

The anti-adherence effect of Lippia sidoides Cham: extract against microorganisms of dental biofilm

Loss of Heterozygosity of p53, BRCA1, VHL, and Estrogen Receptor Genes in Breast Carcinoma: Correlation with Related Protein Products and Morphologic Features

Digital image filters are not necessarily related to improvement in diagnostic of degenerative bone changes in the temporomandibular joint on cone beam computed tomography

Accuracy assessment of different CBCT acquisition protocols used in rapid prototyping models

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