Image-based profiling has emerged as a powerful technology for various steps in basic biological and pharmaceutical discovery, but the community has lacked a large, public reference set of data from chemical and genetic perturbations. Here we present data generated by the Joint Undertaking for Morphological Profiling (JUMP)-Cell Painting Consortium, a collaboration between 10 pharmaceutical companies, six supporting technology companies, and two non-profit partners. When completed, the dataset will contain images and profiles from the Cell Painting assay for over 116,750 unique compounds, over-expression of 12,602 genes, and knockout of 7,975 genes using CRISPR-Cas9, all in human osteosarcoma cells (U2OS). The dataset is estimated to be 115 TB in size and capturing 1.6 billion cells and their single-cell profiles. File quality control and upload is underway and will be completed over the coming months at the Cell Painting Gallery: https://registry.opendata.aws/cellpainting-gallery. A portal to visualize a subset of the data is available at https://phenaid.ardigen.com/jumpcpexplorer/.

InfoSleuth is an agent-based system that can be configured to perform many different information management activities in a distributed environment. InfoSleuth TM agents provide a number of complex query services that require resolving ontology-based queries over dynamically changing, distributed, heterogeneous resources. These include distributed query processing, location-independent single-resource updates, event and information monitoring, statistical or inferential data analysis, and trend discovery in complex event streams. It has been used in numerous applications, including the Environmental Data Exchange Network and the Competitive Intelligence System.Keywords: Multi-agent systems, agent-based systems, information agents, heterogeneous data, query processing, information subscription. 3 Int. J. Coop. Info. Syst. 2000.09:3-27. Downloaded from www.worldscientific.com by NANYANG TECHNOLOGICAL UNIVERSITY on 08/22/15. For personal use only. 4 M. Nodine et al. Fig. 2. Layers of agents. Int. J. Coop. Info. Syst. 2000.09:3-27. Downloaded from www.worldscientific.com by NANYANG TECHNOLOGICAL UNIVERSITY on 08/22/15. For personal use only. 6 M. Nodine et al.

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