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Background. The frequent expansion of the energy drinks (EDs) market has caused an extensive increase in the consumption of EDs, especially among younger populations. However, the lack of knowledge on EDs and their perceived beneficial effects could lead to excessive EDs consumption, which is strongly associated with serious side effects. This study aimed to assess the knowledge and perceived beneficial effects of EDs consumers and determine the consumption patterns and side effects experienced by different EDs consumers among the Malaysian population. Methods. A descriptive cross-sectional study was conducted in Malaysia from February to April 2021. A structured and validated questionnaire, consisting of 5 sections with 46 items, was distributed online. Only 515 out of 591 invited participants agreed to participate in the study. Descriptive and inferential analysis were done using SPSS. Results. The median age of participants was 23 ± 7.3 years. The majority of participants (65%) were unaware of the active ingredients of EDs, and approximately 40% of them had no idea that EDs contain caffeine. The main reason for consuming EDs was to stay awake (43%), and Red Bull was the most preferred brand (57%). Lack of rest (57%), headache (53%), and nervousness (49%) were the most experienced side effects. A significant difference was observed between consumption patterns and knowledge and perceived beneficial effects ( p < 0.05 ). Our data showed a significant association between respondents’ demographic data (e.g., coffee intake, smoking, and alcohol status) and their consumption pattern. Conclusion. ED consumers in Malaysia were found to have limited knowledge on EDs. Therefore, attention should be drawn to the Ministry of Health regarding the significant side effects such as palpitation and nervousness experienced by ED consumers. Hence, awareness ought to be raised by adopting regulations or policies to regulate the sales and warning labels of EDs in Malaysia.

Introduction: The prospect of public accessing community pharmacies for minor ailment advice or treatment highly depends on the pharmacy attributes and their staff. This study aimed to investigate the extent to which community pharmacies are used as a source of minor illness management and the public’s relative preferences for pharmacy features. Methods: A cross-sectional survey among the public in Malaysia was carried out between August and December 2020. The validated self-administered questionnaires were distributed at several pharmacies and shared via email, Whatsapp group, and Facebook. Results: A total of 141 from 153 public respondents completed the survey. From the descriptive and inferential analysis, it was found that about a third of the public goes to a pharmacy for advice or treatment for minor illnesses. The vast majority of respondents had positive perceptions that community pharmacists are knowledgeable and qualified to offer advice or treatment for minor diseases. A significant positive relationship was observed between pharmacy characteristics’ scores and pharmacy staff and pharmacy services’ scores (p<0.001). The increase in pharmacy staff score significantly increased the pharmacy services’ score (p<0.001). Conclusion: The implications of the public acknowledging specific attributes were crucial in further supporting community pharmacists’ services, especially in the private practice setting.

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Conclusions HOXC6 could upregulate DKK1, Wnt/b-catenin pathways and induce EMT which contributed to metastasis in colorectal cancer. Further, we will explore the mechanisms of how upregulation of DKK1 could activate Wnt/b-catenin pathway.

Stroke is among the most significant disease burden globally, with upper middle-income countries having the highest prevalence. Worldwide stroke burden is credited to modifiable risk factors related to underlying comorbidities and the patients' lifestyle. Non-adherence to medication is an added liability which cause substantial loss in terms of money, time, and effort of various stakeholders. There is a lack of behavioural interventions with significant results to overcome intentional non-adherence to stroke preventative medication. A narrative review was selected for analysis to gain a general understanding and defining of intentional non-adherence. The results of this review identified several criteria of perception, belief, and attitude of stroke patients' intrinsic and extrinsic characteristics of medication taking and treatment behaviour which are potential modifiable factors to sustain stroke prevention.