AbstractN-succinyl chitosan (NSC) remains a promising chitosan derivative to develop targeted drug delivery, wound dressings, and tissue engineering systems. All these systems are important in life sciences. NSC is an amphiprotic derivative obtained from the N-acylation of chitosan. NSC exhibits extraordinary biocompatibility, significantly increased aqueous solubility in acidic and basic media without affecting the biological properties, appreciable transfection efficiency, and the ability to stimulate osteogenesis. NSC shows enhanced bioavailability, which highlights its potential applications in the biomedical field. This review briefly introduces chitosan, including its limitations as a biomaterial, and modifications of chitosan with a particular focus on acylation, along with a comprehensive overview of the synthesis, characterization, properties, biodistribution, and toxicological/biopharmaceutical profile of NSC. Furthermore, it extensively surveys current state-of-the-art NSC-based formulations for drug delivery with special emphasis on protein delivery, anti-cancer activity in the colon, as well as nasal and ophthalmic targeted gene/drug delivery. Moreover, it discusses NSC-based biomaterial applications in articular, adipose, and bone tissue engineering. In addition, it describes recent contributions of NSC-based hydrogels in wound dressings along with a brief account of drug delivery in combination with tissue engineering. Finally, it presents potential current challenges and future perspectives of NSC-based formulations in the biomedical field.

Flexible AC Transmission Systems (FACTS) play an important role in minimizing power losses and voltage deviations while increasing the real power transfer capacity of transmission lines. The extent to which these devices can provide benefits to the transmission network depend on their optimal location and sizing. However, finding appropriate locations and sizes of these devices in an electrical network is difficult since it is a nonlinear problem. This paper proposes a technique for the optimal placement and sizing of FACTS, namely the Thyristor-Controlled Series Compensators (TCSCs), Shunt VARs Compensators (SVCs), and Unified Power Flows Controllers (UPFCs). To find the optimal locations of these devices in a network, weak buses and lines are determined by constructing PV curves of load buses, and through the line stability index. Then, the whale optimization algorithm (WOA) is employed not only to find an ideal ratings for these devices but also the optimal coordination of SVC, TCSC, and UPFC with the reactive power sources already present in the network (tap settings of transformers and reactive power from generators). The objective here is the minimization of the operating cost of the system that consists of active power losses and FACTS devices cost. The proposed method is applied to the IEEE 14 and 30 bus systems. The presented technique is also compared with Genetic Algorithm (GA) and Particle Swarm Optimization (PSO). The findings showed that total system operating costs and transmission line losses were considerably reduced by WOA as compared to existing metaheuristic optimization techniques.

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Robust estimates of absolute abundance are vital for management of threatened species, but these have rarely been generated for endangered South Asian river dolphins due to methodological challenges. An estimate of abundance for the Indus River dolphin in 2006 was generated by conducting tandem vessel-based direct counts; conditional likelihood capture-recapture models were then used to correct for missed animals. Group size and sighting conditions were included as covariates, and abundances of the 3 largest subpopulations were estimated as 101 (coefficient of variation, CV = 44.1%) between Chashma and Taunsa barrages, 52 (CV = 14.9%) between Taunsa barrage and Ghazi Ghat, and 1289 (CV = 33.4%) between Guddu and Sukkur barrages. A total of 75.3% of groups were seen by both independent survey teams, and single animals were almost 5 times more likely to be missed than groups of 3 or more. Providing groups can be matched with minimal error, this survey method shows good potential for abundance estimation of dolphins in confined habitat and the shallow rivers of South Asia. Dolphin encounter rates within the Guddu-Sukkur subpopulation (10.35 km −1 ) are the highest reported for any river dolphin. Direct counts conducted over a 35 yr period, suggest that this subpopulation may have been increasing in abundance, probably due to the cessation of hunting and possible immigration from other subpopulations. The future of South Asian river dolphins is intimately tied to water security in the region, and escalating and competing demands for freshwater mean that the long-term future of South Asia's river dolphins is uncertain.

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