New triazole‐imidazole and tetrazole‐imidazole hybrids were obtained using 2,4,5‐triaryl‐1‐(4‐aminophenyl) imidazoles by copper‐catalyzedazide‐alkyne cycloaddition (CuAAC) and Ugi‐azidefour‐component(UA‐4CRs) process. The synthesis of triazole hybrids was performed in the presence of new copper‐incorporated white sandstone nanocatalyst, which was fully characterized by different methods. The construction of newly prepared hybrids was confirmed by spectroscopic techniques. Some of these compounds were evaluated for their anti‐cancer properties against MCF‐7 cancer cell lines. The absorption and emission parameters of the triazole‐ and tetrazole‐substituted imidazoles were also investigated and compared with each other.

A simple, convenient and four-component method for synthesis of 1,2,3,4-tetrasubstituted pyrroles has been developed by using of magnesium containing nano silica catalyst. This strategy demonstrates the coupling reactions of aromatic aldehydes, 1,3-dicarbonyl compounds, aniline derivatives and nitromethane, over the one pot procedure. The polysubstituted 4-(imidazole-1-yl) aniline derivatives were also used as amine precursor at above reaction and the obtained products were evaluated on their emission properties. The modified natural source white sandstone which was appeared as an efficient, recyclable and green catalyst at the desired reaction, was fully characterized by different methods.

Reactions of 1,4,5-triaryl-2-(4-bromomethyl)phenyl-imidazoles with sodium azide in acetone give the corresponding azidomethyl derivatives, which on 1,3-dipolar cycloaddition with various terminal alkynes in the presence of CuI afford novel 1,2,3-triazole products. On the other hand, treatment of 2,4,5-triaryl-1-(4-hydroxyphenyl)-imidazoles with propargyl chloride in the presence of a base gives the corresponding propargyl ether derivatives, which under CuI-catalyzed 1,3-dipolar cycloaddition with benzyl azide produce 1,2,3-triazole derivatives. All the products are characterized from their spectroscopic data and most are evaluated for fluorescence emission. The optical parameters of the studied products are also reported.

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