Magnesium Incorporated White Sandstone as a Green and Efficient Heterogeneous Catalyst for One‐Pot Synthesis of 1,2,3,4‐Tetrasubstituted Pyrroles

Abstract

A simple, convenient and four-component method for synthesis of 1,2,3,4-tetrasubstituted pyrroles has been developed by using of magnesium containing nano silica catalyst. This strategy demonstrates the coupling reactions of aromatic aldehydes, 1,3-dicarbonyl compounds, aniline derivatives and nitromethane, over the one pot procedure. The polysubstituted 4-(imidazole-1-yl) aniline derivatives were also used as amine precursor at above reaction and the obtained products were evaluated on their emission properties. The modified natural source white sandstone which was appeared as an efficient, recyclable and green catalyst at the desired reaction, was fully characterized by different methods.

Nanocatalysts: applications for the synthesis of N-containing five-membered heterocycles

“…Fakhree et al demonstrated the proficient solvent-free synthesis of 1,2,3,4-tetrasubstituted pyrrole derivatives using green magnesium-integrated white sandstone as a novel heterogeneous catalyst through the four component one-pot reaction of 1,3-dicarbonyl compounds, aromatic aldehydes, aniline derivatives and nitromethane. 38 Their work revealed that a superior yield of the desired product was obtained when the catalyst loading was 10% w/w at 80 °C ( Scheme 9 ). The activity of the catalyst did not decrease for up to five successive reactions.…”

Solvent‐Free Synthesis of Pyrroles: An Overview

“…Fakhree and co-workers employed magnesium incorporated white sandstone as a new green heterogeneous catalyst in the solvent-free synthesis of 1,2,3,4-tetrasubstituted pyrrole derivatives for the first time. [79] The reaction proceeded via a four-component one-pot reaction between 1,3-dicarbonyl compounds, aromatic aldehydes, aniline derivatives and nitromethane. The higher yield was obtained when the reaction conditions were optimized using a 10% W/W catalyst at 80 °C (Scheme 24).…”