Nanocatalysts: applications for the synthesis of N-containing five-membered heterocycles

Abstract

This review article demonstrates the various synthetic pathways of five-membered nitrogen-containing heterocycles such as pyrroles, pyrazoles, imidazoles, triazoles and tetrazoles catalysed by metallic nanocatalysts.

Novel isatin–triazole based thiosemicarbazones as potential anticancer agents: synthesis, DFT and molecular docking studies

“…The incorporation of triazole can enhance solubility and facilitate binding to biomolecular targets through a range of noncovalent interactions. 22 Triazoles exhibit a broad spectrum of biological activities, encompassing antimicrobial, 23 antiviral, 24 analgesic, 25 anti-inammatory, 26 antileishmanial, 26,27 and anticancer 28,29 activities. The development of resistance to drugs used to treat different diseases is a serious problem which needs to be addressed.…”

Cu(II)‐Catalyzed Green Synthesis of 1,4,5‐Trisubstituted‐1,2,3‐Triazoles from Chalcone Derivatives – Studies on Their Cytotoxicity Profile

“…Numerous N-heterocyclic compounds have been extensively synthesized due to their widespread utility in medicinal, sensing and catalytic applications. [1][2][3][4] A subtle change in the electronic and steric properties of remote substituents in the molecules can modify the structural and binding properties when they are associated with the biological substrates. [5,6] It is always imperative to design and synthesize new molecules of such useful N-heterocyclic compounds required for the applications.…”

A Core Structure Candidate for Small Molecule Acceptors: Synthesis and DFT Study of Furan Substituted 1,2,4‐Triazole Derivatives

“…Heterocyclic chemistry is a fascinating field for developing effective methods and inventing biological and functional materials [1] . There is a significant and growing interest in the chemistry of five‐membered N‐heterocyclic compounds, primarily triazoles, oxadiazoles, and thiadiazoles [2,3] . They are crucial building blocks for developing new pharmaceuticals, [4,5] natural products, [6,7] and organic electronic materials [8,9] .…”

“…[1] There is a significant and growing interest in the chemistry of five-membered N-heterocyclic compounds, primarily triazoles, oxadiazoles, and thiadiazoles. [2,3] They are crucial building blocks for developing new pharmaceuticals, [4,5] natural products, [6,7] and organic electronic materials. [8,9] Triazole is an important five-membered heterocyclic structure with three nitrogen atoms and is found in the form of two isomers, 1,2,3-triazoles and 1,2,4-triazoles, as illustrated in Figure 1.…”