Cu(II)‐Catalyzed Green Synthesis of 1,4,5‐Trisubstituted‐1,2,3‐Triazoles from Chalcone Derivatives – Studies on Their Cytotoxicity Profile
Joydip Mondal,
Akella Sivaramakrishna
Abstract:Triazoles are an important class of heterocyclic compounds due to their interesting structural features and versatile biological significance. In this regard, the present work highlights the synthesis of Cu(II)‐catalyzed 1,2,3‐trisubstituted triazoles through the cycloaddition of different chalcones with azides under neat methodology. A series of 16 triazole derivatives (3 a to 3 o) was prepared using 10 mol % Cu(II) complexes of 1,10‐phenanthroline and terpyridine‐based ligands as catalysts with moderate to e… Show more
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