Triple-negative breast cancer (TNBC) lacks prognostic and predictive markers. Here, we use high-throughput phosphoproteomics to build a functional TNBC taxonomy. A cluster of 159 phosphosites is upregulated in relapsed cases of a training set (n = 34 patients), with 11 hyperactive kinases accounting for this phosphoprofile. A mass-spectrometry-to-immunohistochemistry translation step, assessing 2 independent validation sets, reveals 6 kinases with preserved independent prognostic value. The kinases split the validation set into two patterns: one without hyperactive kinases being associated with a >90% relapse-free rate, and the other one showing ≥1 hyperactive kinase and being associated with an up to 9.5-fold higher relapse risk. Each kinase pattern encompasses different mutational patterns, simplifying mutation-based taxonomy. Drug regimens designed based on these 6 kinases show promising antitumour activity in TNBC cell lines and patient-derived xenografts. In summary, the present study elucidates phosphosites and kinases implicated in TNBC and suggests a target-based clinical classification system for TNBC.

We report the case of a 35-year-old woman with deep-red asymptomatic macules on the plantar and dorsal skin of the right great toe. Histopathologic fi ndings were compatible with Angioma serpiginosum. Immunohistochemical stains for estrogens and progesterone receptors were negative. Dermoscopy showed an erythematous parallel ridge pattern with double rows of irregular dots and globules. We report an unusual case of angioma serpiginosum with acral volar skin involvement. The dermoscopic features described may aid in the diagnosis of AS in this specifi c skin area. Acral volar skin involvement must be included in the clinical spectrum of Angioma serpiginosum and in the differential diagnosis of acral vascular lesions.

platelet activation and improves skin vascularization. Moreover, iloprost was efficacious in a case of calciphylaxis. 9 HLU and calciphylaxis share a common increase in local vascular resistance and clinical aspect. 10 In our series, five patients received concomitant skin grafting. Considering that skin grafts were previously unsuccessful in all patients of our series, iloprost may enhance the efficacy of the graft. Our case series suggests that iloprost, alone or as adjuvant treatment to skin grafting, may be a potential and safe therapeutic option in patients with severe HLU with failure of previous skin grafts. Larger series are warranted to confirm our results. Acknowledgement The patients in this manuscript have given written informed consent to the publication of their case details.

A 52-year-old woman had a 28-year history of DLE, which exhibited clinically with disfiguring, erythematous and scaly plaques with atrophic scars of the face, neck, and upper back (Figure 1). DLE was histopathologically confirmed (Figure 2).

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