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Keywords: Liquid fermentation; corn hull extract; fumonisin; FB1; Fusarium proliferatum

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The coronavirus disease (COVID-19) pandemic has negatively impacted the well-being of many college students, particularly lesbian, gay, bisexual, transgender, queer, and questioning (LGBTQ+) students who are already at a disproportionate risk for negative mental health and well-being outcomes. To identify potential risk and protective factors we examined LGBTQ+ college students' disclosure of sexual orientation, gender identity, or both (SOGI) to mothers and fathers, living arrangements (whether or not students lived with mothers and fathers), social support from family and friends, and parent-child relationship quality and their association with stress, depressive symptoms, anxiety symptoms, and problem drinking during the pandemic. LGBTQ+ college students (N = 366; M age = 20.4) completed an online survey. Students who reported more social support from family and friends and better quality relationships with mothers or fathers had better well-being and were less likely to perceive a substantial decrease in their well-being due to the pandemic. In contrast, SOGI disclosure and whether or not students lived with mothers or fathers were generally unrelated to well-being. Findings suggest that universities should consider offering mental health resources for students living on-and off-campus, and that clinical professionals should consider strategies to help these young adults identify and maintain support systems and highlight the value of positive parent-child relationships.

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Characteristics of emerging adulthood may make college students less likely to engage in COVID-protective behaviors, a public health concern given that lesbian, gay, bisexual, transgender, queer, and questioning (LGBTQ+) students may be particularly vulnerable to complications related to COVID-19. To identify individual and contextual factors related to COVID-protective behaviors among a sample of LGBTQ+ college students in the United States, we examined differences in COVID-protective and -risk behaviors by gender identity, living arrangement, statewide stay at home orders, and political liberalism of the student’s current state. Although engagement in COVID-protective behaviors was high overall, students who identified as men, did not live with a parent, lived in a state without a stay at home order, and/or lived in a less liberal state engaged in fewer COVID-protective behaviors and more frequent COVID-risk behaviors. Findings underscore the importance of clear public health messaging around COVID-protective behaviors that targets especially vulnerable college students.

I use social exchange theory to contextualize relationship processes associated with relationship stability in asexualallosexual couples and to propose directions for future research. Social exchange theory suggests that asexualallosexual couples might experience varied relationship exchanges compared to other relationship types based on costs/benefits, equity, and available alternatives. These exchanges may also be influenced by differences in relationship commitment and power. I review literature on sexual desire, sexual frequency, willingness to engage in sexual behavior, asexual identity acceptance, and extradyadic behavior to examine how these relationship processes are associated with relationship maintenance for asexual-allosexual couples. Such relationship processes are not necessarily unique to asexual-allosexual couples, but partner expectations may be particularly different in asexual-allosexual couples, thus altering their relationship exchanges. Further research may provide a nuanced understanding of asexual-allosexual relationship maintenance, and recommendations for how to promote healthy interactions and relationship satisfaction in asexualallosexual couples.

Introduction Coronary microvascular dysfunction is characterized by impaired endothelial‐dependent vasodilation. These impairments are seen in diabetic cardiomyopathy (DCM), coronary artery disease (CAD) and ischemia with non‐obstructive coronary artery (INOCA), Takotsubo cardiomyopathy, myocardial infarction with non‐obstructive coronary artery disease (MINOCA), and heart failure with preserved ejection fraction (HFpEF), but detailed mechanisms have yet to be elucidated. Methods microRNA‐21 (miR‐21) global and conditional knockout mice were used to study how miR‐21 regulates coronary microcirculation in pathological conditions like DCM. Both genetic (db/db) and diet‐induced diabetic models were used. Coronary arteries were isolated, and endothelial‐dependent vasodilation was assessed using myography (DMT). In vivo myocardial blood flow (MBF) under stress was measured by contrast echocardiography or doppler after the treatment with different dosages of norepinephrine. Quantitative polymerase chain reaction (qPCR) was performed for gene expression analysis. Trichrome staining and histology were performed for structural changes of the hearts. Results Our preliminary data show that miR‐21 is upregulated in DCM and the deficiency of miR‐21 restores the endothelial‐dependent vasodilation in isolated diabetic coronary arterioles and coronary blood flow under stress in DCM through the mechanism that miR‐21 prevents the mediator of coronary vasodilation switching from NO to H2O2 in diabetes. Conclusions miR‐21 regulates microvascular dysfunction in DCM. Further genetic profiling will elucidate the pathways and mechanisms converging with miR‐21 to regulate microvascular function.